Bus Indianapolis to San Diego - Compare all Companies

Compare all timetables for the bus from Indianapolis to San Diego

Here is a selection of the cheapest bus trips from the schedule from Indianapolis to San Diego from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

Friday

$329

Saturday

Sunday

Monday

Tuesday

$286

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	56h 35m	8:35 AM	Indianapolis	Washington / Delaware	2:10 PM	San Diego	Old Town Transit Center	Economy	$329	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/19/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/21/2025 2:10:00 PM. 50 Economy ticket for $329 per person are available. Travel duration is 56h 35m
FlixBus	56h 5m	8:35 AM	Indianapolis	Washington / Delaware	1:40 PM	San Diego	La Jolla Village	Economy	$329	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/19/2025 8:35:00 AM to La Jolla Village, San Diego (USA) arriving at 12/21/2025 1:40:00 PM. 50 Economy ticket for $329 per person are available. Travel duration is 56h 5m
Greyhound US	53h 15m	11:25 AM	Indianapolis	Central Bus Station	1:40 PM	San Diego	La Jolla Village	Economy	$346	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/19/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/21/2025 1:40:00 PM. 50 Economy ticket for $346 per person are available. Travel duration is 53h 15m
Greyhound US	53h 45m	11:25 AM	Indianapolis	Central Bus Station	2:10 PM	San Diego	Old Town Transit Center	Economy	$349	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/19/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/21/2025 2:10:00 PM. 50 Economy ticket for $349 per person are available. Travel duration is 53h 45m
Greyhound US	73h 0m	8:10 PM	Indianapolis	Central Bus Station	6:10 PM	San Diego	Old Town Transit Center	Economy	$372	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/19/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/22/2025 6:10:00 PM. 50 Economy ticket for $372 per person are available. Travel duration is 73h 0m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	62h 5m	11:30 PM	Indianapolis	Washington / Delaware	10:35 AM	San Diego	San Ysidro Transit Center	Economy	$286	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/23/2025 11:30:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/26/2025 10:35:00 AM. 50 Economy ticket for $286 per person are available. Travel duration is 62h 5m
Greyhound US	54h 15m	11:25 AM	Indianapolis	Central Bus Station	2:40 PM	San Diego	San Ysidro Transit Center	Economy	$289	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/23/2025 11:25:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 12/25/2025 2:40:00 PM. 50 Economy ticket for $289 per person are available. Travel duration is 54h 15m
Greyhound US	49h 40m	8:05 PM	Indianapolis	Central Bus Station	6:45 PM	San Diego	San Ysidro Transit Center	Economy	$312	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/23/2025 8:05:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/25/2025 6:45:00 PM. 50 Economy ticket for $312 per person are available. Travel duration is 49h 40m
FlixBus	57h 5m	8:35 AM	Indianapolis	Washington / Delaware	2:40 PM	San Diego	San Ysidro Transit Center	Economy	$334	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/23/2025 8:35:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 12/25/2025 2:40:00 PM. 50 Economy ticket for $334 per person are available. Travel duration is 57h 5m
FlixBus	60h 15m	9:30 AM	Indianapolis	Washington / Delaware	6:45 PM	San Diego	San Ysidro Transit Center	Economy	$341	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/23/2025 9:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 12/25/2025 6:45:00 PM. 50 Economy ticket for $341 per person are available. Travel duration is 60h 15m

Best Price Offer: The price for the cheapest bus from Indianapolis to San Diego is $235 on 12/24/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Indianapolis and San Diego

See here how frequent the connections between Indianapolis and San Diego are, during different times and days of the week.

Friday is the busiest day, with more than 18 daily buses from Indianapolis to San Diego. Tuesday has instead the fewest connections, with only 5 daily coaches between Indianapolis and San Diego.

The busiest time of the day is the Evening, with 12 buses from Indianapolis to San Diego, while Afternoon sees the fewest connections between Indianapolis and San Diego, with 4 offers.

Facts about the bus from Indianapolis to San Diego

Compare all providers like FlixBus and Greyhound US that travel 11 times every day by bus from Indianapolis to San Diego in one click! Book your bus ticket from Indianapolis to San Diego starting from $235!

Cheapest Bus	$235
Fastest Bus	45h 30m
Earliest Bus	8:35 AM
Latest Bus	11:30 PM
Daily Bus Routes	11 Ø
Distance	1,785.2 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Indianapolis to San Diego

Every day, 11 buses from 2 bus companies leave Indianapolis for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/17/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

$329

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

$286

Wednesday 12/24

$235

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from Indianapolis to San Diego

See here on which day and which time of the day you can find the cheapest bus ticket from Indianapolis to San Diego, for the next 30 days.

With a price starting from $286, Tuesday is the cheapest day for a bus from Indianapolis to San Diego. Friday instead is the most expensive day with prices starting from $329.

Evening is the cheapest day time for bus tickets from Indianapolis to San Diego, with $286. Afternoon is the most expensive time of the day with prices starting from $431.

How to save money travelling from Indianapolis to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Indianapolis to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Indianapolis to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Indianapolis to San Diego are also emptier.

All bus stations and stops in Indianapolis and San Diego

In the map below, you can see where to find all bus stations in Indianapolis and San Diego.

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

La Jolla Village

Hyatt Regency

Service and Comfort on the bus from Indianapolis to San Diego

Want to know which seat classes are available on the buses from Indianapolis to San Diego? Or which bus companies serve the route Indianapolis to San Diego? Below you will find answers to your questions.

FAQs about the Indianapolis to San Diego bus

How much does a Indianapolis San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $235 and takes 59h 5m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Indianapolis to San Diego?

This route is offered by 2 companies with a range of ticket prices between $235 and $471. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Indianapolis to San Diego each day?

Every day, the Indianapolis to San Diego bus route is served by approximately 11 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Indianapolis to San Diego take?

The fastest bus from Indianapolis to San Diego is offered by Greyhound US and takes 45h 30m. Bus tickets for this connection cost $471. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Indianapolis to San Diego?

The earliest bus arriving in San Diego from Indianapolis starts at 8:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Indianapolis to San Diego?

The latest bus trip departing from Indianapolis for San Diego starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Indianapolis San Diego route?

When traveling by bus from Indianapolis to San Diego, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Indianapolis and San Diego?

You can check all the direct connections between Indianapolis and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Indianapolis to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Indianapolis San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Indianapolis San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Indianapolis to San Diego on your planned travel date.

How does CheckMyBus find the best bus deals from Indianapolis to San Diego?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 11 daily trips between Indianapolis and San Diego. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Indianapolis to San Diego?

Prices and availability for 11 trips between Indianapolis and San Diego change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Indianapolis to San Diego

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Indianapolis and to San Diego

Here’s an overview of the most popular bus routes to Indianapolis and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!