Bus from La Serena to Santiago, RM from $7

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Compare all timetables for the bus from La Serena to Santiago, RM

Here is a selection of the cheapest bus trips from the schedule from La Serena to Santiago, RM from various bus operators like Cikbus Elité, Pullman Bus or Nueva Andimar Vip for the next days.
today
from $8
tomorrow
from $8
Sunday
from $9
Monday
from $7
Tuesday
from $7
Wednesday
from $7
Thursday
from $7

Cheapest bus trips today

Prices are for one way and one person
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $8
  • Cikbus Elité
    5h 40m
    0
    5:20 PM
    La Serena
    Bus Station
    11:00 PM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    $8
  • Pluss Chile
    6h 40m
    0
    12:05 AM
    La Serena
    Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $10
  • Condor Bus
    6h 15m
    0
    1:45 AM
    La Serena
    Bus Station
    8:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $12
  • Turbus
    6h 15m
    0
    1:45 AM
    La Serena
    Bus Station
    8:00 AM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $12

Cheapest bus trips tomorrow

Prices are for one way and one person
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $8
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Bus Stop
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9
  • Pluss Chile
    6h 40m
    0
    12:05 AM
    La Serena
    Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $10
  • FlixBus
    6h 5m
    0
    2:00 PM
    La Serena
    Bus Station
    8:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $11
  • Condor Bus
    7h 10m
    0
    9:45 PM
    La Serena
    Bus Station
    4:55 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $12

Cheapest bus trips Sunday

Prices are for one way and one person
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Bus Stop
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9
  • Pluss Chile
    6h 30m
    0
    2:45 AM
    La Serena
    Bus Station
    9:15 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $10
  • Condor Bus
    6h 15m
    0
    1:45 AM
    La Serena
    Bus Station
    8:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $12
  • Turbus
    6h 15m
    0
    1:45 AM
    La Serena
    Bus Station
    8:00 AM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $12
  • Pullman Bus
    6h 0m
    0
    6:00 AM
    La Serena
    El Sto, 1060
    12:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    $12

Cheapest bus trips Monday

Prices are for one way and one person
  • Turbus
    6h 15m
    0
    4:50 AM
    La Serena
    Bus Stop
    11:05 AM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $7
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $8
  • Cikbus Elité
    5h 55m
    0
    1:35 AM
    La Serena
    Bus Stop
    7:30 AM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $10
  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $11
  • Pullman Bus
    6h 30m
    0
    12:00 PM
    La Serena
    El Sto, 1060
    6:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    $12

Cheapest bus trips Tuesday

Prices are for one way and one person
  • Turbus
    6h 30m
    0
    4:00 PM
    La Serena
    Bus Stop
    10:30 PM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $7
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $8
  • Pluss Chile
    6h 40m
    0
    12:05 AM
    La Serena
    Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $10
  • Cikbus Elité
    7h 20m
    0
    1:10 AM
    La Serena
    Bus Station
    8:30 AM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    $10
  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $11

Cheapest bus trips Wednesday

Prices are for one way and one person
  • Turbus
    6h 15m
    0
    4:50 AM
    La Serena
    Bus Stop
    11:05 AM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $7
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $8
  • FlixBus
    6h 5m
    0
    2:00 PM
    La Serena
    Bus Station
    8:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $8
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Bus Stop
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9
  • Pluss Chile
    6h 40m
    0
    12:05 AM
    La Serena
    Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $10

Cheapest bus trips Thursday

Prices are for one way and one person
  • Turbus
    6h 15m
    0
    4:50 AM
    La Serena
    Bus Stop
    11:05 AM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $7
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $8
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Bus Stop
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9
  • Condor Bus
    6h 15m
    0
    1:45 AM
    La Serena
    Bus Station
    8:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $12
  • Pullman Bus
    6h 0m
    0
    12:45 AM
    La Serena
    El Sto, 1060
    6:45 AM
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    $12

Frequency of bus connections between La Serena and Santiago, RM

See here how frequent the connections between La Serena and Santiago, RM are, during different times and days of the week.
Friday is the busiest day, with more than 320 daily buses from La Serena to Santiago, RM. Monday has instead the fewest connections, with only 194 daily coaches between La Serena and Santiago, RM.
The busiest time of the day is the Morning, with 570 buses from La Serena to Santiago, RM, while Evening sees the fewest connections between La Serena and Santiago, RM, with 228 offers.

Facts about the bus from La Serena to Santiago, RM

Compare all providers like Cikbus Elité, Pullman Bus and Nueva Andimar Vip that travel 257 times every day by bus from La Serena to Santiago, RM in one click! Book your bus ticket from La Serena to Santiago, RM starting from $7!

Cheapest Bus $7
Fastest Bus 5h 10m
Earliest Bus 12:05 AM
Latest Bus 11:59 PM
Daily Bus Routes 257 Ø
Distance 247.0 miles
Bus Companies Cikbus Elité, Pullman Bus, Nueva Andimar Vip, Pluss Chile, FlixBus, Pullman San Andres, Turbus, Buses Romani, Cormar Bus, Condor Bus and 2 more.

Cheapest bus connections from La Serena to Santiago, RM

Every day, 257 buses from 12 bus companies leave La Serena for Santiago, RM: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/25/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 04/20
Monday 04/21
Tuesday 04/22
Wednesday 04/23
Thursday 04/24
Friday 04/25
$9
Saturday 04/26
$9
Sunday 04/27
$12
Monday 04/28
$7
Tuesday 04/29
$8
Wednesday 04/30
$14
Thursday 05/01
$9
Friday 05/02
$10
Saturday 05/03
$14
Sunday 05/04
$13
Monday 05/05
$14
Tuesday 05/06
$7
Wednesday 05/07
$7
Thursday 05/08
$7
Friday 05/09
$7
Saturday 05/10
$7
Sunday 05/11
$17
Monday 05/12
$7
Tuesday 05/13
$7
Wednesday 05/14
$7
Thursday 05/15
$7
Friday 05/16
$7
Saturday 05/17

The cheapest time to travel from La Serena to Santiago, RM

See here on which day and which time of the day you can find the cheapest bus ticket from La Serena to Santiago, RM, for the next 30 days.
With a price starting from $7, Monday is the cheapest day for a bus from La Serena to Santiago, RM. Sunday instead is the most expensive day with prices starting from $9.
Afternoon is the cheapest day time for bus tickets from La Serena to Santiago, RM, with $7. Evening is the most expensive time of the day with prices starting from $10.

How to save money travelling from La Serena to Santiago, RM

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from La Serena to Santiago, RM in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from La Serena to Santiago, RM, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from La Serena to Santiago, RM are also emptier.

Beloved bus companies from La Serena to Santiago, RM

These are the most booked bus companies between La Serena to Santiago, RM from our users.

Buses Romani from La Serena to Santiago, RM

Buses Romani

Here you will find the key facts about the Buses Romani bus route La Serena to Santiago, RM:

Cheapest Price $8
Fastest Bus 5h 45m
Earliest Bus 12:30 AM
Last Bus 11:15 PM
Daily Connections 10 Ø
Found on 4/24/2025

Cikbus Elité from La Serena to Santiago, RM

Cikbus Elité

Here you will find the key facts about the Cikbus Elité bus route La Serena to Santiago, RM:

Cheapest Price $8
Fastest Bus 5h 10m
Earliest Bus 12:50 AM
Last Bus 11:59 PM
Daily Connections 54 Ø
Found on 4/25/2025

Condor Bus from La Serena to Santiago, RM

Condor Bus

Here you will find the key facts about the Condor Bus bus route La Serena to Santiago, RM:

Cheapest Price $12
Fastest Bus 6h 15m
Earliest Bus 1:45 AM
Last Bus 11:00 PM
Daily Connections 8 Ø
Found on 4/24/2025

Latest reviews for bus companies on the route La Serena - Santiago, RM

Pluss Chile
Esteban Guerrero, 1/29/2025

Compré un pasaje de 6 horas en salón premium adelante en el parabrisas no había nada de espacio. Ultima vez que viajo en plus chile

All bus stations and stops in La Serena and Santiago, RM

In the map below, you can see where to find all bus stations in La Serena and Santiago, RM.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from La Serena to Santiago, RM? Compare all modes of transports from La Serena to Santiago, RM.

Service and Comfort on the bus from La Serena to Santiago, RM

Want to know which seat classes are available on the buses from La Serena to Santiago, RM? Or which bus companies serve the route La Serena to Santiago, RM? Below you will find answers to your questions.

FAQs about the La Serena to Santiago, RM bus

How much does a La Serena Santiago, RM bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $7 and takes 6h 15m to reach Santiago, RM. Compare offers to save money!

How much could I save by comparing buses from La Serena to Santiago, RM?

This route is offered by 12 companies with a range of ticket prices between $7 and $35. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santiago, RM.

On average, how many connections are available from La Serena to Santiago, RM each day?

Every day, the La Serena to Santiago, RM bus route is served by approximately 257 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from La Serena to Santiago, RM take?

The fastest bus from La Serena to Santiago, RM is offered by Cikbus Elité and takes 5h 10m. Bus tickets for this connection cost $24. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from La Serena to Santiago, RM?

The earliest bus arriving in Santiago, RM from La Serena starts at 12:05 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from La Serena to Santiago, RM?

The latest bus trip departing from La Serena for Santiago, RM starts at 11:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the La Serena Santiago, RM route?

When traveling by bus from La Serena to Santiago, RM, passengers can travel with Cikbus Elité, Pullman Bus and Nueva Andimar Vip. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between La Serena and Santiago, RM?

You can check all the direct connections between La Serena and Santiago, RM by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Cikbus Elité, Pullman Bus and Nueva Andimar Vip.

What can I take with me on the La Serena to Santiago, RM bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the La Serena Santiago, RM bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the La Serena Santiago, RM bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from La Serena to Santiago, RM on your planned travel date.

Available seat classes which are offered on the bus route La Serena to Santiago, RM

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy
PremiumEconomy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

Business
Business

Comfortable seating, food and drink service, accompanied generally by ticket flexibility.

First Class
First

Best of the best: you will find the most comfortable accommodation to work or relax during your travel.

More bus routes to La Serena and to Santiago, RM

Here’s an overview of the most popular bus routes to La Serena and to Santiago, RM. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses Valparaíso (CL) to La Serena Buses Valparaíso (CL) to La Serena
Buses Viña del Mar to La Serena Buses Viña del Mar to La Serena
Bus Calama - La Serena Bus Calama - La Serena
Bus to La Serena from Iquique Bus to La Serena from Iquique
Buses Concepción - Santiago, RM Buses Concepción - Santiago, RM
From Temuco to Santiago, RM bus From Temuco to Santiago, RM bus
Bus to Santiago, RM from Puerto Varas Bus to Santiago, RM from Puerto Varas
Concón to Santiago, RM bus Concón to Santiago, RM bus
Popular Airport Shuttles to La Serena and to Santiago, RM
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