Bus Mesa, AZ to San Antonio, TX - Compare all Companies

Compare all timetables for the bus from Mesa, AZ to San Antonio, TX

Here is a selection of the cheapest bus trips from the schedule from Mesa, AZ to San Antonio, TX from various bus operators like Greyhound US for the next days.

today

$212

tomorrow

Sunday

$181

Monday

Tuesday

Wednesday

$164

Thursday

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	27h 40m	7:15 PM	Mesa, AZ	Greyhound	11:55 PM	San Antonio, TX	Bus Station		Economy	$212	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 12/19/2025 7:15:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/20/2025 11:55:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 27h 40m

Did you know that if you travel from Mesa, AZ to San Antonio, TX via Las Cruces, NM, you can save more than $25? You can find the corresponding connections below.
- Busbud
  
  38h 45m
  
  0
  
  8:40 AM
  
  Mesa, AZ
  Greyhound
  
  3:45 PM
  
  Las Cruces, NM
  Mesilla Valley Intermodal Transit Terminal
  
  0
  
  Economy
  
  $52
  
  A Bus from Busbud goes from Greyhound, Mesa, AZ (USA) at 12/20/2025 8:40:00 AM to Mesilla Valley Intermodal Transit Terminal, Las Cruces, NM (USA) arriving at 12/20/2025 3:45:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 7h 5m
- FlixBus
  
  12h 35m
  
  0
  
  10:50 AM
  
  Las Cruces, NM
  Mesilla Valley Intermodal Transit Terminal
  
  12:25 AM
  
  San Antonio, TX
  Bus Station
  
  0
  
  Economy
  
  $135
  
  A Bus from FlixBus goes from Mesilla Valley Intermodal Transit Terminal, Las Cruces, NM (USA) at 12/21/2025 10:50:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/22/2025 12:25:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 12h 35m
Travel time is 10h 5m longer, but you will save $25

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	19h 35m	3:50 AM	Mesa, AZ	Greyhound	12:25 AM	San Antonio, TX	Bus Station	Economy	$181	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 12/21/2025 3:50:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/22/2025 12:25:00 AM. 50 Economy ticket for $181 per person are available. Travel duration is 19h 35m
Greyhound US	27h 15m	8:40 AM	Mesa, AZ	Greyhound	12:55 PM	San Antonio, TX	Bus Station	Economy	$247	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 12/21/2025 8:40:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/22/2025 12:55:00 PM. 50 Economy ticket for $247 per person are available. Travel duration is 27h 15m
Greyhound US	27h 40m	7:15 PM	Mesa, AZ	Greyhound	11:55 PM	San Antonio, TX	Bus Station	Economy	$260	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 12/21/2025 7:15:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/22/2025 11:55:00 PM. 50 Economy ticket for $260 per person are available. Travel duration is 27h 40m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 15m	8:40 AM	Mesa, AZ	Greyhound	12:55 PM	San Antonio, TX	Bus Station	Economy	$164	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 12/24/2025 8:40:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/25/2025 12:55:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 27h 15m
Greyhound US	27h 40m	7:15 PM	Mesa, AZ	Greyhound	11:55 PM	San Antonio, TX	Bus Station	Economy	$164	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 12/24/2025 7:15:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/25/2025 11:55:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 27h 40m
Greyhound US	19h 35m	3:50 AM	Mesa, AZ	Greyhound	12:25 AM	San Antonio, TX	Bus Station	Economy	$165	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 12/24/2025 3:50:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/25/2025 12:25:00 AM. 50 Economy ticket for $165 per person are available. Travel duration is 19h 35m

Best Price Offer: The price for the cheapest bus from Mesa, AZ to San Antonio, TX is $154 on 12/19/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Mesa, AZ and San Antonio, TX

See here how frequent the connections between Mesa, AZ and San Antonio, TX are, during different times and days of the week.

Sunday is the busiest day, with more than 3 daily buses from Mesa, AZ to San Antonio, TX. Friday has instead the fewest connections, with only 1 daily coaches between Mesa, AZ and San Antonio, TX.

The busiest time of the day is the Evening, with 3 buses from Mesa, AZ to San Antonio, TX, while Morning sees the fewest connections between Mesa, AZ and San Antonio, TX, with 2 offers.

Facts about the bus from Mesa, AZ to San Antonio, TX

Compare all providers like Greyhound US that travel 2 times every day by bus from Mesa, AZ to San Antonio, TX in one click! Book your bus ticket from Mesa, AZ to San Antonio, TX starting from $154!

Cheapest Bus	$154
Fastest Bus	20h 35m
Earliest Bus	7:15 PM
Latest Bus	7:15 PM
Daily Bus Routes	2 Ø
Distance	833.1 miles
Bus Companies	Greyhound US

Cheapest bus connections from Mesa, AZ to San Antonio, TX

Every day, 2 buses from 1 bus companies leave Mesa, AZ for San Antonio, TX: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

$154

Saturday 12/20

Sunday 12/21

$181

Monday 12/22

Tuesday 12/23

Wednesday 12/24

$164

Thursday 12/25

Friday 12/26

$173

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from Mesa, AZ to San Antonio, TX

See here on which day and which time of the day you can find the cheapest bus ticket from Mesa, AZ to San Antonio, TX, for the next 30 days.

With a price starting from $154, Friday is the cheapest day for a bus from Mesa, AZ to San Antonio, TX. Sunday instead is the most expensive day with prices starting from $181.

Night is the cheapest day time for bus tickets from Mesa, AZ to San Antonio, TX, with $154. Evening is the most expensive time of the day with prices starting from $164.

How to save money travelling from Mesa, AZ to San Antonio, TX

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Mesa, AZ to San Antonio, TX in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Mesa, AZ to San Antonio, TX, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Mesa, AZ to San Antonio, TX are also emptier.

All bus stations and stops in Mesa, AZ and San Antonio, TX

In the map below, you can see where to find all bus stations in Mesa, AZ and San Antonio, TX.

Greyhound

S Country Club Dr 1423

Fry’s Fuel Center

W Main Street 1235

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

W. Southcross & Buffalo Bus Stop

Commerce & Bowie Bus Stop

Service and Comfort on the bus from Mesa, AZ to San Antonio, TX

Want to know which seat classes are available on the buses from Mesa, AZ to San Antonio, TX? Or which bus companies serve the route Mesa, AZ to San Antonio, TX? Below you will find answers to your questions.

FAQs about the Mesa, AZ to San Antonio, TX bus

How much does a Mesa, AZ San Antonio, TX bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $154 and takes 28h 15m to reach San Antonio, TX. Compare offers to save money!

How much could I save by comparing buses from Mesa, AZ to San Antonio, TX?

This route is offered by 1 companies with a range of ticket prices between $154 and $260. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Antonio, TX.

On average, how many connections are available from Mesa, AZ to San Antonio, TX each day?

Every day, the Mesa, AZ to San Antonio, TX bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Mesa, AZ to San Antonio, TX take?

The fastest bus from Mesa, AZ to San Antonio, TX is offered by Greyhound US and takes 20h 35m. Bus tickets for this connection cost $181. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Mesa, AZ to San Antonio, TX?

The earliest bus arriving in San Antonio, TX from Mesa, AZ starts at 7:15 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Mesa, AZ to San Antonio, TX?

The latest bus trip departing from Mesa, AZ for San Antonio, TX starts at 7:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Mesa, AZ San Antonio, TX route?

When traveling by bus from Mesa, AZ to San Antonio, TX, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Mesa, AZ and San Antonio, TX?

You can check all the direct connections between Mesa, AZ and San Antonio, TX by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Mesa, AZ to San Antonio, TX bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Mesa, AZ San Antonio, TX bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Mesa, AZ San Antonio, TX bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mesa, AZ to San Antonio, TX on your planned travel date.

How does CheckMyBus find the best bus deals from Mesa, AZ to San Antonio, TX?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Mesa, AZ and San Antonio, TX. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Mesa, AZ to San Antonio, TX?

Prices and availability for 2 trips between Mesa, AZ and San Antonio, TX change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Mesa, AZ to San Antonio, TX

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Mesa, AZ and to San Antonio, TX

Here’s an overview of the most popular bus routes to Mesa, AZ and to San Antonio, TX. Simply click on the connection of your choice, and you will find all the details about your bus route!