Bus San Diego to Indianapolis: Compare prices and save money

Compare all timetables for the bus from San Diego to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from San Diego to Indianapolis from various bus operators like FlixBus or Greyhound US for the next days.

today

from $184

tomorrow

from $163

Saturday

Sunday

from $174

Monday

Tuesday

Wednesday

from $161

Cheapest bus trips today

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	50h 0m	9:30 AM	San Diego	La Jolla Village	2:30 PM	Indianapolis	Central Bus Station	Economy	$184	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 8/14/2025 9:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 8/16/2025 2:30:00 PM. 50 Economy ticket for $184 per person are available. Travel duration is 50h 0m
FlixBus	57h 25m	9:00 AM	San Diego	Old Town Transit Center	9:25 PM	Indianapolis	Washington / Delaware	Economy	$185	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 8/14/2025 9:00:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 8/16/2025 9:25:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 57h 25m
FlixBus	56h 55m	9:30 AM	San Diego	La Jolla Village	9:25 PM	Indianapolis	Washington / Delaware	Economy	$185	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 8/14/2025 9:30:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 8/16/2025 9:25:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 56h 55m
Greyhound US	49h 30m	10:00 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$186	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 8/14/2025 10:00:00 AM to Central Bus Station, Indianapolis (USA) arriving at 8/16/2025 2:30:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 49h 30m
Greyhound US	50h 20m	2:00 PM	San Diego	Old Town Transit Center	7:20 PM	Indianapolis	Central Bus Station	Economy	$193	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 8/14/2025 2:00:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/16/2025 7:20:00 PM. 50 Economy ticket for $193 per person are available. Travel duration is 50h 20m

Cheapest bus trips tomorrow

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	54h 15m	10:00 AM	San Diego	Old Town Transit Center	7:15 PM	Indianapolis	Downtown Transit Center	Economy	$163	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 8/15/2025 10:00:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 8/17/2025 7:15:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 54h 15m
FlixBus	56h 40m	7:35 AM	San Diego	Old Town Transit Center	7:15 PM	Indianapolis	Downtown Transit Center	Economy	$168	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 8/15/2025 7:35:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 8/17/2025 7:15:00 PM. 50 Economy ticket for $168 per person are available. Travel duration is 56h 40m
Greyhound US	49h 30m	10:00 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$173	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 8/15/2025 10:00:00 AM to Central Bus Station, Indianapolis (USA) arriving at 8/17/2025 2:30:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 49h 30m
FlixBus	50h 30m	9:00 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$174	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 8/15/2025 9:00:00 AM to Central Bus Station, Indianapolis (USA) arriving at 8/17/2025 2:30:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 50h 30m
Greyhound US	50h 20m	2:00 PM	San Diego	Old Town Transit Center	7:20 PM	Indianapolis	Central Bus Station	Economy	$175	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 8/15/2025 2:00:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/17/2025 7:20:00 PM. 50 Economy ticket for $175 per person are available. Travel duration is 50h 20m

Cheapest bus trips Sunday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	57h 50m	7:35 PM	San Diego	Old Town Transit Center	8:25 AM	Indianapolis	Downtown Transit Center	Economy	$174	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 8/17/2025 7:35:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 8/20/2025 8:25:00 AM. 50 Economy ticket for $174 per person are available. Travel duration is 57h 50m
Greyhound US	54h 15m	7:35 PM	San Diego	Old Town Transit Center	4:50 AM	Indianapolis	Central Bus Station	Economy	$175	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 8/17/2025 7:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/20/2025 4:50:00 AM. 50 Economy ticket for $175 per person are available. Travel duration is 54h 15m
FlixBus	55h 15m	6:35 PM	San Diego	Old Town Transit Center	4:50 AM	Indianapolis	Central Bus Station	Economy	$178	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 8/17/2025 6:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/20/2025 4:50:00 AM. 50 Economy ticket for $178 per person are available. Travel duration is 55h 15m
Greyhound US	49h 30m	10:00 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$178	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 8/17/2025 10:00:00 AM to Central Bus Station, Indianapolis (USA) arriving at 8/19/2025 2:30:00 PM. 50 Economy ticket for $178 per person are available. Travel duration is 49h 30m
FlixBus	58h 50m	6:35 PM	San Diego	Old Town Transit Center	8:25 AM	Indianapolis	Downtown Transit Center	Economy	$179	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 8/17/2025 6:35:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 8/20/2025 8:25:00 AM. 50 Economy ticket for $179 per person are available. Travel duration is 58h 50m

Cheapest bus trips Wednesday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	52h 10m	12:10 PM	San Diego	Old Town Transit Center	7:20 PM	Indianapolis	Central Bus Station	Economy	$161	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 8/20/2025 12:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/22/2025 7:20:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 52h 10m
FlixBus	51h 40m	12:40 PM	San Diego	La Jolla Village	7:20 PM	Indianapolis	Central Bus Station	Economy	$161	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 8/20/2025 12:40:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/22/2025 7:20:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 51h 40m
FlixBus	56h 55m	9:30 AM	San Diego	La Jolla Village	9:25 PM	Indianapolis	Washington / Delaware	Economy	$163	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 8/20/2025 9:30:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 8/22/2025 9:25:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 56h 55m
Greyhound US	59h 10m	7:15 AM	San Diego	Old Town Transit Center	9:25 PM	Indianapolis	Washington / Delaware	Economy	$164	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 8/20/2025 7:15:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 8/22/2025 9:25:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 59h 10m
Greyhound US	52h 15m	7:15 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$165	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 8/20/2025 7:15:00 AM to Central Bus Station, Indianapolis (USA) arriving at 8/22/2025 2:30:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 52h 15m

Best Price Offer: The price for the cheapest bus from San Diego to Indianapolis is $150 on 8/22/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between San Diego and Indianapolis

See here how frequent the connections between San Diego and Indianapolis are, during different times and days of the week.

Thursday is the busiest day, with more than 17 daily buses from San Diego to Indianapolis. Friday has instead the fewest connections, with only 12 daily coaches between San Diego and Indianapolis.

The busiest time of the day is the Morning, with 28 buses from San Diego to Indianapolis, while Afternoon sees the fewest connections between San Diego and Indianapolis, with 5 offers.

Facts about the bus from San Diego to Indianapolis

Compare all providers like FlixBus and Greyhound US that travel 13 times every day by bus from San Diego to Indianapolis in one click! Book your bus ticket from San Diego to Indianapolis starting from $150!

Cheapest Bus	$150
Fastest Bus	52h 30m
Earliest Bus	7:35 AM
Latest Bus	7:35 PM
Daily Bus Routes	13 Ø
Distance	1,785.2 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from San Diego to Indianapolis

Every day, 13 buses from 2 bus companies leave San Diego for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/14/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 08/10

Monday 08/11

Tuesday 08/12

Wednesday 08/13

Thursday 08/14

$184

Friday 08/15

$161

Saturday 08/16

Sunday 08/17

$174

Monday 08/18

Tuesday 08/19

Wednesday 08/20

$158

Thursday 08/21

Friday 08/22

$150

Saturday 08/23

Sunday 08/24

Monday 08/25

Tuesday 08/26

Wednesday 08/27

Thursday 08/28

Friday 08/29

Saturday 08/30

Sunday 08/31

Monday 09/01

Tuesday 09/02

Wednesday 09/03

Thursday 09/04

Friday 09/05

Saturday 09/06

The cheapest time to travel from San Diego to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Indianapolis, for the next 30 days.

With a price starting from $150, Friday is the cheapest day for a bus from San Diego to Indianapolis. Thursday instead is the most expensive day with prices starting from $184.

Afternoon is the cheapest day time for bus tickets from San Diego to Indianapolis, with $161. Evening is the most expensive time of the day with prices starting from $174.

How to save money travelling from San Diego to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Indianapolis are also emptier.

All bus stations and stops in San Diego and Indianapolis

In the map below, you can see where to find all bus stations in San Diego and Indianapolis.

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Downtown

Seaport Village

W Harbor Dr 789

La Jolla Village

Hyatt Regency

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from San Diego to Indianapolis

Want to know which seat classes are available on the buses from San Diego to Indianapolis? Or which bus companies serve the route San Diego to Indianapolis? Below you will find answers to your questions.

FAQs about the San Diego to Indianapolis bus

How much does a San Diego Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $150 and takes 55h 10m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from San Diego to Indianapolis?

This route is offered by 2 companies with a range of ticket prices between $150 and $207. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from San Diego to Indianapolis each day?

Every day, the San Diego to Indianapolis bus route is served by approximately 13 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Indianapolis take?

The fastest bus from San Diego to Indianapolis is offered by Greyhound US and takes 52h 30m. Bus tickets for this connection cost $186. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Indianapolis?

The earliest bus arriving in Indianapolis from San Diego starts at 7:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Indianapolis?

The latest bus trip departing from San Diego for Indianapolis starts at 7:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Indianapolis route?

When traveling by bus from San Diego to Indianapolis, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Indianapolis?

You can check all the direct connections between San Diego and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Indianapolis on your planned travel date.

Available seat classes which are offered on the bus route San Diego to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Indianapolis

Here’s an overview of the most popular bus routes to San Diego and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!