Bus Santa Ana, CA to San Francisco: Compare prices and save money

Compare all timetables for the bus from Santa Ana, CA to San Francisco

Here is a selection of the cheapest bus trips from the schedule from Santa Ana, CA to San Francisco from various bus operators like Greyhound US for the next days.

today

tomorrow

$86

Wednesday

Thursday

$132

Friday

$148

Saturday

$49

Sunday

$124

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	12h 35m	7:30 PM	Santa Ana, CA	Bus Stop	8:05 AM	San Francisco	5th/Townsend		Economy	$86	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/16/2025 7:30:00 PM to 5th/Townsend, San Francisco (USA) arriving at 12/17/2025 8:05:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 12h 35m
	Greyhound US	9h 55m	9:20 PM	Santa Ana, CA	Bus Stop	7:15 AM	San Francisco	Bus Station Transbay		Economy	$104	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/16/2025 9:20:00 PM to Bus Station Transbay, San Francisco (USA) arriving at 12/17/2025 7:15:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 9h 55m

Did you know that if you travel from Santa Ana, CA to San Francisco via Los Angeles, you can save more than $18? You can find the corresponding connections below.
- FlixBus
  
  12h 15m
  
  0
  
  7:30 PM
  
  Santa Ana, CA
  Bus Stop
  
  9:15 PM
  
  Los Angeles
  Union Station
  
  0
  
  Economy
  
  $13
  
  A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 12/16/2025 7:30:00 PM to Union Station, Los Angeles (USA) arriving at 12/16/2025 9:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 1h 45m
- Busbud
  
  7h 20m
  
  0
  
  12:25 AM
  
  Los Angeles
  Expo / Sepulveda
  
  7:45 AM
  
  San Francisco
  5th/Townsend
  
  0
  
  Economy
  
  $55
  
  A Bus from Busbud goes from Expo / Sepulveda, Los Angeles (USA) at 12/17/2025 12:25:00 AM to 5th/Townsend, San Francisco (USA) arriving at 12/17/2025 7:45:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 7h 20m
Travel time is 2h 20m longer, but you will save $18

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	9h 55m	9:20 PM	Santa Ana, CA	Bus Stop	7:15 AM	San Francisco	Bus Station Transbay		Economy	$132	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/18/2025 9:20:00 PM to Bus Station Transbay, San Francisco (USA) arriving at 12/19/2025 7:15:00 AM. 50 Economy ticket for $132 per person are available. Travel duration is 9h 55m

Did you know that if you travel from Santa Ana, CA to San Francisco via Anaheim, CA, you can save more than $0? You will find the corresponding connections below.
- Save more than 1%
  
  9h 35m
  
  Santa Ana, CA
  
  7 mi
  
  9:40 PM
  
  Anaheim, CA
  Anaheim Regional Transportation Intermodal Center
  
  7:15 AM
  
  San Francisco
  Bus Station Transbay
  
  0 mi
  
  Economy
  
  $132
  
  A Bus from goes from Anaheim Regional Transportation Intermodal Center, Anaheim, CA (USA) at 12/18/2025 9:40:00 PM to Bus Station Transbay, San Francisco (USA) arriving at 12/19/2025 7:15:00 AM. 50 Economy ticket for $132 per person are available. Travel duration is 9h 35m
Did you know that if you travel from Santa Ana, CA to San Francisco via Los Angeles, you can save more than $64? You can find the corresponding connections below.
- FlixBus
  
  12h 15m
  
  0
  
  7:30 PM
  
  Santa Ana, CA
  Bus Stop
  
  9:15 PM
  
  Los Angeles
  Union Station
  
  0
  
  Economy
  
  $13
  
  A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 12/16/2025 7:30:00 PM to Union Station, Los Angeles (USA) arriving at 12/16/2025 9:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 1h 45m
- Busbud
  
  7h 20m
  
  0
  
  12:25 AM
  
  Los Angeles
  Expo / Sepulveda
  
  7:45 AM
  
  San Francisco
  5th/Townsend
  
  0
  
  Economy
  
  $55
  
  A Bus from Busbud goes from Expo / Sepulveda, Los Angeles (USA) at 12/17/2025 12:25:00 AM to 5th/Townsend, San Francisco (USA) arriving at 12/17/2025 7:45:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 7h 20m
Travel time is 2h 20m longer, but you will save $64

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	9h 55m	9:20 PM	Santa Ana, CA	Bus Stop	7:15 AM	San Francisco	Bus Station Transbay		Economy	$148	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/19/2025 9:20:00 PM to Bus Station Transbay, San Francisco (USA) arriving at 12/20/2025 7:15:00 AM. 50 Economy ticket for $148 per person are available. Travel duration is 9h 55m

Did you know that if you travel from Santa Ana, CA to San Francisco via Anaheim, CA, you can save more than $0? You will find the corresponding connections below.
- Save more than 1%
  
  9h 35m
  
  Santa Ana, CA
  
  7 mi
  
  9:40 PM
  
  Anaheim, CA
  Anaheim Regional Transportation Intermodal Center
  
  7:15 AM
  
  San Francisco
  Bus Station Transbay
  
  0 mi
  
  Economy
  
  $148
  
  A Bus from goes from Anaheim Regional Transportation Intermodal Center, Anaheim, CA (USA) at 12/19/2025 9:40:00 PM to Bus Station Transbay, San Francisco (USA) arriving at 12/20/2025 7:15:00 AM. 50 Economy ticket for $148 per person are available. Travel duration is 9h 35m
Did you know that if you travel from Santa Ana, CA to San Francisco via Los Angeles, you can save more than $80? You can find the corresponding connections below.
- FlixBus
  
  12h 15m
  
  0
  
  7:30 PM
  
  Santa Ana, CA
  Bus Stop
  
  9:15 PM
  
  Los Angeles
  Union Station
  
  0
  
  Economy
  
  $13
  
  A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 12/16/2025 7:30:00 PM to Union Station, Los Angeles (USA) arriving at 12/16/2025 9:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 1h 45m
- Busbud
  
  7h 20m
  
  0
  
  12:25 AM
  
  Los Angeles
  Expo / Sepulveda
  
  7:45 AM
  
  San Francisco
  5th/Townsend
  
  0
  
  Economy
  
  $55
  
  A Bus from Busbud goes from Expo / Sepulveda, Los Angeles (USA) at 12/17/2025 12:25:00 AM to 5th/Townsend, San Francisco (USA) arriving at 12/17/2025 7:45:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 7h 20m
Travel time is 2h 20m longer, but you will save $80

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	11h 10m	7:30 PM	Santa Ana, CA	Bus Stop	6:40 AM	San Francisco	5th/Townsend	Economy	$49	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/20/2025 7:30:00 PM to 5th/Townsend, San Francisco (USA) arriving at 12/21/2025 6:40:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 11h 10m
Greyhound US	11h 20m	8:45 AM	Santa Ana, CA	Bus Stop	8:05 PM	San Francisco	5th/Townsend	Economy	$51	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/20/2025 8:45:00 AM to 5th/Townsend, San Francisco (USA) arriving at 12/20/2025 8:05:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 11h 20m
Greyhound US	9h 55m	9:20 PM	Santa Ana, CA	Bus Stop	7:15 AM	San Francisco	Salesforce Transit Center	Economy	$67	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/20/2025 9:20:00 PM to Salesforce Transit Center, San Francisco (USA) arriving at 12/21/2025 7:15:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 9h 55m

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	9h 55m	9:20 PM	Santa Ana, CA	Bus Stop	7:15 AM	San Francisco	Bus Station Transbay		Economy	$124	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/21/2025 9:20:00 PM to Bus Station Transbay, San Francisco (USA) arriving at 12/22/2025 7:15:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 9h 55m
	Greyhound US	12h 35m	7:30 PM	Santa Ana, CA	Bus Stop	8:05 AM	San Francisco	5th/Townsend		Economy	$136	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/21/2025 7:30:00 PM to 5th/Townsend, San Francisco (USA) arriving at 12/22/2025 8:05:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 12h 35m

Did you know that if you travel from Santa Ana, CA to San Francisco via Anaheim, CA, you can save more than $0? You will find the corresponding connections below.
- Save more than 1%
  
  9h 35m
  
  Santa Ana, CA
  
  7 mi
  
  9:40 PM
  
  Anaheim, CA
  Anaheim Regional Transportation Intermodal Center
  
  7:15 AM
  
  San Francisco
  Bus Station Transbay
  
  0 mi
  
  Economy
  
  $124
  
  A Bus from goes from Anaheim Regional Transportation Intermodal Center, Anaheim, CA (USA) at 12/21/2025 9:40:00 PM to Bus Station Transbay, San Francisco (USA) arriving at 12/22/2025 7:15:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 9h 35m
Did you know that if you travel from Santa Ana, CA to San Francisco via Los Angeles, you can save more than $56? You can find the corresponding connections below.
- FlixBus
  
  12h 15m
  
  0
  
  7:30 PM
  
  Santa Ana, CA
  Bus Stop
  
  9:15 PM
  
  Los Angeles
  Union Station
  
  0
  
  Economy
  
  $13
  
  A Bus from FlixBus goes from Bus Stop, Santa Ana, CA (USA) at 12/16/2025 7:30:00 PM to Union Station, Los Angeles (USA) arriving at 12/16/2025 9:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 1h 45m
- Busbud
  
  7h 20m
  
  0
  
  12:25 AM
  
  Los Angeles
  Expo / Sepulveda
  
  7:45 AM
  
  San Francisco
  5th/Townsend
  
  0
  
  Economy
  
  $55
  
  A Bus from Busbud goes from Expo / Sepulveda, Los Angeles (USA) at 12/17/2025 12:25:00 AM to 5th/Townsend, San Francisco (USA) arriving at 12/17/2025 7:45:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 7h 20m
Travel time is 2h 20m longer, but you will save $56

Best Price Offer: The price for the cheapest bus from Santa Ana, CA to San Francisco is $49 on 12/20/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Santa Ana, CA and San Francisco

See here how frequent the connections between Santa Ana, CA and San Francisco are, during different times and days of the week.

Saturday is the busiest day, with more than 3 daily buses from Santa Ana, CA to San Francisco. Thursday has instead the fewest connections, with only 1 daily coaches between Santa Ana, CA and San Francisco.

The busiest time of the day is the Evening, with 8 buses from Santa Ana, CA to San Francisco, while Morning sees the fewest connections between Santa Ana, CA and San Francisco, with 1 offers.

Facts about the bus from Santa Ana, CA to San Francisco

Compare all providers like Greyhound US that travel 1 times every day by bus from Santa Ana, CA to San Francisco in one click! Book your bus ticket from Santa Ana, CA to San Francisco starting from $49!

Cheapest Bus	$49
Fastest Bus	9h 55m
Earliest Bus	7:30 PM
Latest Bus	9:20 PM
Daily Bus Routes	1 Ø
Distance	376.9 miles
Bus Companies	Greyhound US

Cheapest bus connections from Santa Ana, CA to San Francisco

Every day, 1 buses from 1 bus companies leave Santa Ana, CA for San Francisco: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/15/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

$86

Wednesday 12/17

Thursday 12/18

$132

Friday 12/19

$148

Saturday 12/20

$49

Sunday 12/21

$124

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

$67

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from Santa Ana, CA to San Francisco

See here on which day and which time of the day you can find the cheapest bus ticket from Santa Ana, CA to San Francisco, for the next 30 days.

With a price starting from $49, Saturday is the cheapest day for a bus from Santa Ana, CA to San Francisco. Friday instead is the most expensive day with prices starting from $147.

Evening is the cheapest day time for bus tickets from Santa Ana, CA to San Francisco, with $49. Morning is the most expensive time of the day with prices starting from $50.

How to save money travelling from Santa Ana, CA to San Francisco

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santa Ana, CA to San Francisco in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santa Ana, CA to San Francisco, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santa Ana, CA to San Francisco are also emptier.

Beloved bus companies from Santa Ana, CA to San Francisco

These are the most booked bus companies between Santa Ana, CA to San Francisco from our users.

Greyhound US from Santa Ana, CA to San Francisco

Here you will find the key facts about the Greyhound US bus route Santa Ana, CA to San Francisco:

Cheapest Price	$49
Fastest Bus	9h 55m
Earliest Bus	7:30 PM
Last Bus	9:20 PM
Daily Connections	1 Ø
Found on	12/13/2025

All bus stations and stops in Santa Ana, CA and San Francisco

In the map below, you can see where to find all bus stations in Santa Ana, CA and San Francisco.

Bus Stop

1000 E Santa Ana Blvd 105

Train Station

W 1st St 101-155

Bus Station Transbay

Folsom Street 200

South Van Ness Ave & Market St

Beach St & Hyde St

Union Square

Post St 470

One Ferry Building

Passenger Loading Zone in front of Ferry Building on Embarcadero. Bus will stop near Marketbar Cafe.

Service and Comfort on the bus from Santa Ana, CA to San Francisco

Want to know which seat classes are available on the buses from Santa Ana, CA to San Francisco? Or which bus companies serve the route Santa Ana, CA to San Francisco? Below you will find answers to your questions.

FAQs about the Santa Ana, CA to San Francisco bus

How much does a Santa Ana, CA San Francisco bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $49 and takes 11h 10m to reach San Francisco. Compare offers to save money!

How much could I save by comparing buses from Santa Ana, CA to San Francisco?

This route is offered by 1 companies with a range of ticket prices between $49 and $148. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Francisco.

On average, how many connections are available from Santa Ana, CA to San Francisco each day?

Every day, the Santa Ana, CA to San Francisco bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santa Ana, CA to San Francisco take?

The fastest bus from Santa Ana, CA to San Francisco is offered by Greyhound US and takes 9h 55m. Bus tickets for this connection cost $104. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santa Ana, CA to San Francisco?

The earliest bus arriving in San Francisco from Santa Ana, CA starts at 7:30 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santa Ana, CA to San Francisco?

The latest bus trip departing from Santa Ana, CA for San Francisco starts at 9:20 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santa Ana, CA San Francisco route?

When traveling by bus from Santa Ana, CA to San Francisco, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santa Ana, CA and San Francisco?

You can check all the direct connections between Santa Ana, CA and San Francisco by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Santa Ana, CA to San Francisco bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santa Ana, CA San Francisco bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santa Ana, CA San Francisco bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santa Ana, CA to San Francisco on your planned travel date.

How does CheckMyBus find the best bus deals from Santa Ana, CA to San Francisco?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 1 daily trips between Santa Ana, CA and San Francisco. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Santa Ana, CA to San Francisco?

Prices and availability for 1 trips between Santa Ana, CA and San Francisco change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Santa Ana, CA to San Francisco

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Santa Ana, CA and to San Francisco

Here’s an overview of the most popular bus routes to Santa Ana, CA and to San Francisco. Simply click on the connection of your choice, and you will find all the details about your bus route!