What is the best way to travel from San Diego to St. Louis, MO?
Looking for a trip? Compare all the available Buses and Flights for the journey to St. Louis, MO from San Diego. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach St. Louis, MO from San Diego?
You can get to St. Louis, MO with just $95 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Frontier Airlines18h 51m01:10 PMSan Diego AirportSan Diego Airport10:01 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 4/29/2025 1:10:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/30/2025 10:01:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 18h 51m
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Alaska Airlines10h 23m011:36 AMSan Diego AirportSan Diego Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 4/29/2025 11:36:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/29/2025 11:59:00 PM. 50 Economy ticket for $256 per person are available. Travel duration is 10h 23m
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United Airlines6h 47m07:00 AMSan Diego AirportSan Diego Airport3:47 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 4/29/2025 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/29/2025 3:47:00 PM. 50 Economy ticket for $257 per person are available. Travel duration is 6h 47m
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American Airlines6h 58m06:15 AMSan Diego AirportSan Diego Airport3:13 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 4/29/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/29/2025 3:13:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 6h 58m
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Volaris13h 15m012:41 AMTijuana AirportTijuana Airport3:56 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Volaris goes from Tijuana Airport, Tijuana Airport (Mexico) at 4/29/2025 12:41:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/29/2025 3:56:00 PM. 50 Economy ticket for $335 per person are available. Travel duration is 13h 15m
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 4/29/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/1/2025 12:55:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 50h 25m
Cheapest Flights Tuesday
Cheapest Buses Tuesday
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FlixBus53h 40m05:00 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/1/2025 5:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/3/2025 10:40:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 53h 40m
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FlixBus53h 10m05:00 PMSan DiegoOld Town Transit Center10:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/1/2025 5:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/3/2025 10:10:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 53h 10m
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Greyhound US46h 55m02:00 PMSan DiegoOld Town Transit Center12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/1/2025 2:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/3/2025 12:55:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 46h 55m
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Greyhound US51h 5m07:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/1/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/3/2025 10:40:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 51h 5m
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 5/1/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/3/2025 12:55:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 50h 25m
Cheapest Buses Thursday
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 5/2/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/4/2025 12:55:00 PM. 50 Economy ticket for $248 per person are available. Travel duration is 50h 25m
Cheapest Buses Friday
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Frontier Airlines38h 6m08:00 AMSan Diego AirportSan Diego Airport12:06 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/3/2025 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/5/2025 12:06:00 AM. 50 Economy ticket for $144 per person are available. Travel duration is 38h 6m
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Spirit Airlines34h 1m09:08 PMSan Diego AirportSan Diego Airport9:09 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/3/2025 9:08:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/5/2025 9:09:00 AM. 50 Economy ticket for $170 per person are available. Travel duration is 34h 1m
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Alaska Airlines10h 5m011:54 AMSan Diego AirportSan Diego Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/3/2025 11:54:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/3/2025 11:59:00 PM. 50 Economy ticket for $244 per person are available. Travel duration is 10h 5m
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United Airlines7h 34m06:15 AMSan Diego AirportSan Diego Airport3:49 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/3/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/3/2025 3:49:00 PM. 50 Economy ticket for $260 per person are available. Travel duration is 7h 34m
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American Airlines6h 58m06:15 AMSan Diego AirportSan Diego Airport3:13 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/3/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/3/2025 3:13:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 6h 58m
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FlixBus53h 40m05:00 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/3/2025 5:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/5/2025 10:40:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 53h 40m
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FlixBus53h 10m05:00 PMSan DiegoOld Town Transit Center10:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/3/2025 5:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/5/2025 10:10:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 53h 10m
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FlixBus55h 5m03:35 PMSan DiegoSDSU Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from SDSU Transit Center, San Diego (USA) at 5/3/2025 3:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/5/2025 10:40:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 55h 5m
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Greyhound US46h 55m02:00 PMSan DiegoOld Town Transit Center12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/3/2025 2:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/5/2025 12:55:00 PM. 50 Economy ticket for $198 per person are available. Travel duration is 46h 55m
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Greyhound US51h 5m07:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/3/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/5/2025 10:40:00 PM. 50 Economy ticket for $199 per person are available. Travel duration is 51h 5m
Cheapest Flights Saturday
Cheapest Buses Saturday
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Frontier Airlines10h 14m08:55 PMSan Diego AirportSan Diego Airport9:09 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/4/2025 8:55:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/5/2025 9:09:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 10h 14m
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United Airlines7h 34m06:15 AMSan Diego AirportSan Diego Airport3:49 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/4/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/4/2025 3:49:00 PM. 50 Economy ticket for $259 per person are available. Travel duration is 7h 34m
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Alaska Airlines14h 59m07:00 AMSan Diego AirportSan Diego Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/4/2025 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/4/2025 11:59:00 PM. 50 Economy ticket for $277 per person are available. Travel duration is 14h 59m
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American Airlines6h 58m06:15 AMSan Diego AirportSan Diego Airport3:13 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/4/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/4/2025 3:13:00 PM. 50 Economy ticket for $309 per person are available. Travel duration is 6h 58m
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Spirit Airlines12h 50m06:15 AMSan Diego AirportSan Diego Airport9:05 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/4/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/4/2025 9:05:00 PM. 50 Economy ticket for $315 per person are available. Travel duration is 12h 50m
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Greyhound US45h 5m010:00 AMSan DiegoOld Town Transit Center7:05 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/4/2025 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/6/2025 7:05:00 AM. 50 Economy ticket for $169 per person are available. Travel duration is 45h 5m
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FlixBus46h 5m09:00 AMSan DiegoOld Town Transit Center7:05 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/4/2025 9:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/6/2025 7:05:00 AM. 50 Economy ticket for $171 per person are available. Travel duration is 46h 5m
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Greyhound US50h 35m07:35 PMSan DiegoOld Town Transit Center10:10 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/4/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/6/2025 10:10:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 50h 35m
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FlixBus53h 40m05:00 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/4/2025 5:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/6/2025 10:40:00 PM. 50 Economy ticket for $183 per person are available. Travel duration is 53h 40m
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Greyhound Lines Mexico59h 40m010:30 AMTijuana AirportTijuana Airport10:10 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 5/4/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/6/2025 10:10:00 PM. 50 Economy ticket for $231 per person are available. Travel duration is 59h 40m
Cheapest Flights Sunday
Cheapest Buses Sunday
What are the fastest trips from San Diego to St. Louis, MO?
You can get to St. Louis, MO from San Diego in just 6h 47m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines6h 47m07:00 AMSan Diego AirportSan Diego Airport3:47 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 4/29/2025 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/29/2025 3:47:00 PM. 50 Economy ticket for $257 per person are available. Travel duration is 6h 47m
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American Airlines6h 58m06:15 AMSan Diego AirportSan Diego Airport3:13 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 4/29/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/29/2025 3:13:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 6h 58m
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Alaska Airlines10h 23m011:36 AMSan Diego AirportSan Diego Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 4/29/2025 11:36:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/29/2025 11:59:00 PM. 50 Economy ticket for $256 per person are available. Travel duration is 10h 23m
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Volaris13h 15m012:41 AMTijuana AirportTijuana Airport3:56 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Volaris goes from Tijuana Airport, Tijuana Airport (Mexico) at 4/29/2025 12:41:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/29/2025 3:56:00 PM. 50 Economy ticket for $335 per person are available. Travel duration is 13h 15m
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Frontier Airlines18h 51m01:10 PMSan Diego AirportSan Diego Airport10:01 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 4/29/2025 1:10:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/30/2025 10:01:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 18h 51m
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 4/29/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/1/2025 12:55:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 50h 25m
Fastest Flights Tuesday
Fastest Buses Tuesday
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Greyhound US46h 55m02:00 PMSan DiegoOld Town Transit Center12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/1/2025 2:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/3/2025 12:55:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 46h 55m
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 5/1/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/3/2025 12:55:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 50h 25m
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Greyhound US51h 5m07:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/1/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/3/2025 10:40:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 51h 5m
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FlixBus53h 10m05:00 PMSan DiegoOld Town Transit Center10:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/1/2025 5:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/3/2025 10:10:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 53h 10m
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FlixBus53h 40m05:00 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/1/2025 5:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/3/2025 10:40:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 53h 40m
Fastest Buses Thursday
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 5/2/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/4/2025 12:55:00 PM. 50 Economy ticket for $248 per person are available. Travel duration is 50h 25m
Fastest Buses Friday
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American Airlines6h 58m06:15 AMSan Diego AirportSan Diego Airport3:13 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/3/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/3/2025 3:13:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 6h 58m
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United Airlines7h 34m06:15 AMSan Diego AirportSan Diego Airport3:49 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/3/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/3/2025 3:49:00 PM. 50 Economy ticket for $260 per person are available. Travel duration is 7h 34m
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Alaska Airlines10h 5m011:54 AMSan Diego AirportSan Diego Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/3/2025 11:54:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/3/2025 11:59:00 PM. 50 Economy ticket for $244 per person are available. Travel duration is 10h 5m
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Spirit Airlines34h 1m09:08 PMSan Diego AirportSan Diego Airport9:09 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/3/2025 9:08:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/5/2025 9:09:00 AM. 50 Economy ticket for $170 per person are available. Travel duration is 34h 1m
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Frontier Airlines38h 6m08:00 AMSan Diego AirportSan Diego Airport12:06 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/3/2025 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/5/2025 12:06:00 AM. 50 Economy ticket for $144 per person are available. Travel duration is 38h 6m
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Greyhound US46h 55m02:00 PMSan DiegoOld Town Transit Center12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/3/2025 2:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/5/2025 12:55:00 PM. 50 Economy ticket for $198 per person are available. Travel duration is 46h 55m
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Greyhound US51h 5m07:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/3/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/5/2025 10:40:00 PM. 50 Economy ticket for $199 per person are available. Travel duration is 51h 5m
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FlixBus53h 10m05:00 PMSan DiegoOld Town Transit Center10:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/3/2025 5:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/5/2025 10:10:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 53h 10m
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FlixBus53h 40m05:00 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/3/2025 5:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/5/2025 10:40:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 53h 40m
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FlixBus55h 5m03:35 PMSan DiegoSDSU Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from SDSU Transit Center, San Diego (USA) at 5/3/2025 3:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/5/2025 10:40:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 55h 5m
Fastest Flights Saturday
Fastest Buses Saturday
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American Airlines6h 58m06:15 AMSan Diego AirportSan Diego Airport3:13 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/4/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/4/2025 3:13:00 PM. 50 Economy ticket for $309 per person are available. Travel duration is 6h 58m
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United Airlines7h 34m06:15 AMSan Diego AirportSan Diego Airport3:49 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/4/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/4/2025 3:49:00 PM. 50 Economy ticket for $259 per person are available. Travel duration is 7h 34m
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Frontier Airlines10h 14m08:55 PMSan Diego AirportSan Diego Airport9:09 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/4/2025 8:55:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/5/2025 9:09:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 10h 14m
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Spirit Airlines12h 50m06:15 AMSan Diego AirportSan Diego Airport9:05 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/4/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/4/2025 9:05:00 PM. 50 Economy ticket for $315 per person are available. Travel duration is 12h 50m
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Alaska Airlines14h 59m07:00 AMSan Diego AirportSan Diego Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 5/4/2025 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 5/4/2025 11:59:00 PM. 50 Economy ticket for $277 per person are available. Travel duration is 14h 59m
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Greyhound US45h 5m010:00 AMSan DiegoOld Town Transit Center7:05 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/4/2025 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/6/2025 7:05:00 AM. 50 Economy ticket for $169 per person are available. Travel duration is 45h 5m
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FlixBus46h 5m09:00 AMSan DiegoOld Town Transit Center7:05 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/4/2025 9:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/6/2025 7:05:00 AM. 50 Economy ticket for $171 per person are available. Travel duration is 46h 5m
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Greyhound US50h 35m07:35 PMSan DiegoOld Town Transit Center10:10 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 5/4/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/6/2025 10:10:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 50h 35m
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FlixBus53h 40m05:00 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 5/4/2025 5:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 5/6/2025 10:40:00 PM. 50 Economy ticket for $183 per person are available. Travel duration is 53h 40m
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Greyhound Lines Mexico59h 40m010:30 AMTijuana AirportTijuana Airport10:10 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 5/4/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 5/6/2025 10:10:00 PM. 50 Economy ticket for $231 per person are available. Travel duration is 59h 40m
Fastest Flights Sunday
Fastest Buses Sunday
Here you will find all operators and timetables for a
Bus from San Diego to St. Louis, MO
What are the most popular stations in San Diego and St. Louis, MO?
In San Diego, you will usually depart from Santa Fe Depot, San Ysidro Transit Center or Old Town Transit Center, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to St. Louis, MO from San Diego? With 6 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between San Diego and St. Louis, MO, you can pay as low as $95 with a Flight from Frontier Airlines.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to St. Louis, MO in just 6h 47m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting San Diego and St. Louis, MO are FlixBus, Greyhound US and Greyhound Lines Mexico, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in San Diego and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from San Diego Airport or to Sauget, IL, and look at flights from Tijuana Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from San Diego to St. Louis, MO?
The most popular companies between San Diego and St. Louis, MO, are FlixBus, Greyhound US and Greyhound Lines Mexico. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, Greyhound US and Greyhound Lines Mexico
Airlines: Frontier Airlines, Alaska Airlines, United Airlines and 3 more.
All you need to know when you travel from San Diego to St. Louis, MO
Check all information on comfort and services on all modes of transports from San Diego to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from San Diego to St. Louis, MO
How can I reach St. Louis, MO from San Diego?
Every day, there are on average 6 connections between Bus and Flight, with which you can get to St. Louis, MO from San Diego.
How far is St. Louis, MO from San Diego?
The distance between San Diego and St. Louis, MO is 1,560.7 miles.
What is the most ecofriendly mode of transport between San Diego and St. Louis, MO?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 68 kgs of CO2, a train 88 kgs, a car 427 kgs, and a flight 618 kgs.
What is the cheapest mode of transport from San Diego to St. Louis, MO?
You can get to St. Louis, MO with just $95 by taking a Flight from Frontier Airlines.
What is the fastest way to get from San Diego to St. Louis, MO?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 6h 47m with a Flight from United Airlines.
More routes to San Diego and to St. Louis, MO
Looking for more options? Here you can see the most popular routes to San Diego and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!
- Trips to San Diego
- Dallas to San Diego
- El Paso, TX to San Diego
- Los Angeles to San Diego
- Santa Maria, CA to San Diego
- Trips to St. Louis, MO
- Dallas to St. Louis, MO