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How to get from San Diego to St. Louis, MO

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What is the best way to travel from San Diego to St. Louis, MO?

Looking for a trip? Compare all the available Buses and Flights for the journey to St. Louis, MO from San Diego. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
Flight is the cheapest and fastest way on this route
Transport type
Travel time
Cheapest price
Average price
Daily departures
Bus
44h 15m
$189
$201
13
Flight
6h 34m
$112
$316
46

What is the cheapest way to reach St. Louis, MO from San Diego?

You can get to St. Louis, MO with just $112 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.

today
from $189
tomorrow
Friday
from $150
Saturday
Sunday
from $112
Monday
Tuesday

    Cheapest Buses today

  • FlixBus
    45h 55m
    0
    1:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $189
  • FlixBus
    46h 55m
    0
    12:00 PM
    San Diego
    Seaport Village
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $189
  • FlixBus
    46h 35m
    0
    12:20 PM
    San Diego
    Balboa Park
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $189
  • Greyhound US
    44h 55m
    0
    2:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $191
  • Greyhound US
    49h 5m
    0
    7:35 PM
    San Diego
    Old Town Transit Center
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $201
  • Cheapest Flights today

  • Spirit Airlines
    31h 6m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    3:21 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $246
  • Alaska Airlines
    10h 25m
    0
    10:59 AM
    San Diego Airport
    San Diego Airport
    11:24 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $264
  • Viva Aerobus
    26h 4m
    0
    7:20 PM
    Tijuana Airport
    Tijuana Airport
    11:24 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Viva Aerobus
    Economy
    from $272
  • American Airlines
    7h 0m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    3:15 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $436
  • United Airlines
    7h 29m
    0
    7:00 AM
    San Diego Airport
    San Diego Airport
    4:29 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $457

    Cheapest Flights Friday

  • Frontier Airlines
    23h 48m
    0
    6:25 AM
    San Diego Airport
    San Diego Airport
    8:13 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $150
  • Spirit Airlines
    11h 19m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    7:34 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $221
  • Alaska Airlines
    12h 59m
    0
    9:00 AM
    San Diego Airport
    San Diego Airport
    11:59 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $328
  • Viva Aerobus
    17h 24m
    0
    12:10 AM
    Tijuana Airport
    Tijuana Airport
    7:34 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Viva Aerobus
    Economy
    from $369
  • American Airlines
    9h 17m
    0
    12:55 PM
    San Diego Airport
    San Diego Airport
    12:12 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $406
  • Cheapest Buses Friday

  • FlixBus
    45h 25m
    0
    1:30 PM
    San Diego
    La Jolla Village
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $191
  • Greyhound US
    44h 55m
    0
    2:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $191
  • FlixBus
    45h 55m
    0
    1:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $193
  • Greyhound US
    44h 15m
    0
    9:05 AM
    San Diego
    Old Town Transit Center
    7:20 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $202
  • Greyhound Lines Mexico
    48h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $206

    Cheapest Flights Sunday

  • Frontier Airlines
    23h 48m
    0
    6:25 AM
    San Diego Airport
    San Diego Airport
    8:13 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $112
  • Spirit Airlines
    11h 19m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    7:34 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $230
  • Alaska Airlines
    11h 57m
    0
    8:16 AM
    San Diego Airport
    San Diego Airport
    10:13 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $362
  • American Airlines
    7h 0m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    3:15 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $436
  • United Airlines
    6h 34m
    0
    7:00 AM
    San Diego Airport
    San Diego Airport
    3:34 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $452
  • Cheapest Buses Sunday

  • Greyhound US
    44h 15m
    0
    9:05 AM
    San Diego
    Old Town Transit Center
    7:20 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $212
  • FlixBus
    45h 25m
    0
    1:30 PM
    San Diego
    La Jolla Village
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $213
  • Greyhound US
    44h 55m
    0
    2:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $213
  • FlixBus
    45h 55m
    0
    1:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $214
  • Greyhound Lines Mexico
    48h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $227

What are the fastest trips from San Diego to St. Louis, MO?

You can get to St. Louis, MO from San Diego in just 6h 34m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.

today
from 7h 0m
tomorrow
Friday
from 9h 17m
Saturday
Sunday
from 6h 34m
Monday
Tuesday

    Fastest Flights today

  • American Airlines
    7h 0m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    3:15 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $436
  • United Airlines
    7h 29m
    0
    7:00 AM
    San Diego Airport
    San Diego Airport
    4:29 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $457
  • Alaska Airlines
    10h 25m
    0
    10:59 AM
    San Diego Airport
    San Diego Airport
    11:24 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $264
  • Viva Aerobus
    26h 4m
    0
    7:20 PM
    Tijuana Airport
    Tijuana Airport
    11:24 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Viva Aerobus
    Economy
    from $272
  • Spirit Airlines
    31h 6m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    3:21 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $246
  • Fastest Buses today

  • Greyhound US
    44h 55m
    0
    2:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $191
  • FlixBus
    45h 55m
    0
    1:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $189
  • FlixBus
    46h 35m
    0
    12:20 PM
    San Diego
    Balboa Park
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $189
  • FlixBus
    46h 55m
    0
    12:00 PM
    San Diego
    Seaport Village
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $189
  • Greyhound US
    49h 5m
    0
    7:35 PM
    San Diego
    Old Town Transit Center
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $201

    Fastest Flights Friday

  • American Airlines
    9h 17m
    0
    12:55 PM
    San Diego Airport
    San Diego Airport
    12:12 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $406
  • Spirit Airlines
    11h 19m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    7:34 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $221
  • Alaska Airlines
    12h 59m
    0
    9:00 AM
    San Diego Airport
    San Diego Airport
    11:59 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $328
  • Viva Aerobus
    17h 24m
    0
    12:10 AM
    Tijuana Airport
    Tijuana Airport
    7:34 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Viva Aerobus
    Economy
    from $369
  • Frontier Airlines
    23h 48m
    0
    6:25 AM
    San Diego Airport
    San Diego Airport
    8:13 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $150
  • Fastest Buses Friday

  • Greyhound US
    44h 15m
    0
    9:05 AM
    San Diego
    Old Town Transit Center
    7:20 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $202
  • Greyhound US
    44h 55m
    0
    2:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $191
  • FlixBus
    45h 25m
    0
    1:30 PM
    San Diego
    La Jolla Village
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $191
  • FlixBus
    45h 55m
    0
    1:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $193
  • Greyhound Lines Mexico
    48h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $206

    Fastest Flights Sunday

  • United Airlines
    6h 34m
    0
    7:00 AM
    San Diego Airport
    San Diego Airport
    3:34 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $452
  • American Airlines
    7h 0m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    3:15 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $436
  • Spirit Airlines
    11h 19m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    7:34 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $230
  • Alaska Airlines
    11h 57m
    0
    8:16 AM
    San Diego Airport
    San Diego Airport
    10:13 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $362
  • Frontier Airlines
    23h 48m
    0
    6:25 AM
    San Diego Airport
    San Diego Airport
    8:13 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $112
  • Fastest Buses Sunday

  • Greyhound US
    44h 15m
    0
    9:05 AM
    San Diego
    Old Town Transit Center
    7:20 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $212
  • Greyhound US
    44h 55m
    0
    2:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $213
  • FlixBus
    45h 25m
    0
    1:30 PM
    San Diego
    La Jolla Village
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $213
  • FlixBus
    45h 55m
    0
    1:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $214
  • Greyhound Lines Mexico
    48h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $227
Here you will find all operators and timetables for a Bus from San Diego to St. Louis, MO

What are the most popular stations in San Diego and St. Louis, MO?

In San Diego, you will usually depart from Santa Fe Depot, San Ysidro Transit Center or Old Town Transit Center, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.

How do I decide? Some tips and tricks from our experience

Are you having trouble deciding on how to get to St. Louis, MO from San Diego? With 10 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.

Look for the lowest price

Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between San Diego and St. Louis, MO, you can pay as low as $112 with a Flight from Frontier Airlines.

Travel duration

Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to St. Louis, MO in just 6h 34m.

Comfort makes all the difference

You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting San Diego and St. Louis, MO are FlixBus, Greyhound US and Spirit Airlines, but be sure to check what they have to offer!

Save money with deals, and always compare

One last tip? Even if you live in San Diego and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from San Diego Airport or to Sauget, IL, and look at flights from Tijuana Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!

Which companies offer a trip from San Diego to St. Louis, MO?

The most popular companies between San Diego and St. Louis, MO, are FlixBus, Greyhound US and Spirit Airlines. Be sure to check their seat class offers and the amenities that they provide.

Bus companies: FlixBus, Greyhound US and Greyhound Lines Mexico

Airlines: Spirit Airlines, Alaska Airlines, American Airlines and 3 more.

All you need to know when you travel from San Diego to St. Louis, MO

Check all information on comfort and services on all modes of transports from San Diego to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.

FAQs about the trip from San Diego to St. Louis, MO

How can I reach St. Louis, MO from San Diego?

Every day, there are on average 10 connections between Bus and Flight, with which you can get to St. Louis, MO from San Diego.

How far is St. Louis, MO from San Diego?

The distance between San Diego and St. Louis, MO is 1,560.7 miles.

What is the most ecofriendly mode of transport between San Diego and St. Louis, MO?

Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance. On this particular route, a bus will emit, per person, a total of 68 kgs of CO2, a train 88 kgs, a car 427 kgs, and a flight 618 kgs.

What is the cheapest mode of transport from San Diego to St. Louis, MO?

You can get to St. Louis, MO with just $112 by taking a Flight from Frontier Airlines.

What is the fastest way to get from San Diego to St. Louis, MO?

While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 6h 34m with a Flight from United Airlines.

More routes to San Diego and to St. Louis, MO

Looking for more options? Here you can see the most popular routes to San Diego and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!

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