What is the best way to travel from St. Louis, MO to Pittsburgh?
Looking for a trip? Compare all the available Buses and Flights for the journey to Pittsburgh from St. Louis, MO. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Pittsburgh from St. Louis, MO?
You can get to Pittsburgh with just $75 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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United Airlines5h 44m06:30 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:14 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/4/2025 6:30:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/4/2025 1:14:00 PM. 50 Economy ticket for $324 per person are available. Travel duration is 5h 44m
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United Airlines4h 14m08:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:14 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/4/2025 8:00:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/4/2025 1:14:00 PM. 50 Economy ticket for $324 per person are available. Travel duration is 4h 14m
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Skyscanner4h 35m08:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport2:00 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/4/2025 8:25:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/4/2025 2:00:00 PM. 50 Economy ticket for $324 per person are available. Travel duration is 4h 35m
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Skyscanner4h 49m09:39 AMSt. Louis Lambert AirportSt. Louis Lambert Airport3:28 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/4/2025 9:39:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/4/2025 3:28:00 PM. 50 Economy ticket for $324 per person are available. Travel duration is 4h 49m
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Alaska Airlines10h 52m06:44 AMSt. Louis Lambert AirportSt. Louis Lambert Airport6:36 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Alaska Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/4/2025 6:44:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/4/2025 6:36:00 PM. 50 Economy ticket for $497 per person are available. Travel duration is 10h 52m
Cheapest Flights Friday
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Greyhound US15h 10m02:30 AMSt. Louis, MOGateway Station5:40 PMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/5/2025 2:30:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/5/2025 5:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 10m
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Greyhound US15h 35m08:45 AMSt. Louis, MOGateway Station12:20 AMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/5/2025 8:45:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/6/2025 12:20:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 35m
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Greyhound US13h 55m01:55 PMSt. Louis, MOGateway Station3:50 AMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/5/2025 1:55:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/6/2025 3:50:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 13h 55m
Cheapest Buses Saturday
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Greyhound US15h 10m02:30 AMSt. Louis, MOGateway Station5:40 PMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/7/2025 2:30:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/7/2025 5:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 10m
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Greyhound US15h 35m08:45 AMSt. Louis, MOGateway Station12:20 AMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/7/2025 8:45:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/8/2025 12:20:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 35m
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Greyhound US13h 55m01:55 PMSt. Louis, MOGateway Station3:50 AMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/7/2025 1:55:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/8/2025 3:50:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 13h 55m
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United Airlines5h 44m06:30 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:14 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/7/2025 6:30:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/7/2025 1:14:00 PM. 50 Economy ticket for $359 per person are available. Travel duration is 5h 44m
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United Airlines4h 14m08:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:14 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/7/2025 8:00:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/7/2025 1:14:00 PM. 50 Economy ticket for $359 per person are available. Travel duration is 4h 14m
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Skyscanner4h 35m08:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport2:00 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/7/2025 8:25:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/7/2025 2:00:00 PM. 50 Economy ticket for $359 per person are available. Travel duration is 4h 35m
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Skyscanner4h 49m09:39 AMSt. Louis Lambert AirportSt. Louis Lambert Airport3:28 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/7/2025 9:39:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/7/2025 3:28:00 PM. 50 Economy ticket for $359 per person are available. Travel duration is 4h 49m
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Alaska Airlines26h 25m03:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport6:36 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Alaska Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/7/2025 3:11:00 PM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/8/2025 6:36:00 PM. 50 Economy ticket for $528 per person are available. Travel duration is 26h 25m
Cheapest Buses Monday
Cheapest Flights Monday
What are the fastest trips from St. Louis, MO to Pittsburgh?
You can get to Pittsburgh from St. Louis, MO in just 4h 14m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines4h 14m08:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:14 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/4/2025 8:00:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/4/2025 1:14:00 PM. 50 Economy ticket for $324 per person are available. Travel duration is 4h 14m
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Skyscanner4h 35m08:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport2:00 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/4/2025 8:25:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/4/2025 2:00:00 PM. 50 Economy ticket for $324 per person are available. Travel duration is 4h 35m
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Skyscanner4h 49m09:39 AMSt. Louis Lambert AirportSt. Louis Lambert Airport3:28 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/4/2025 9:39:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/4/2025 3:28:00 PM. 50 Economy ticket for $324 per person are available. Travel duration is 4h 49m
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United Airlines5h 44m06:30 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:14 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/4/2025 6:30:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/4/2025 1:14:00 PM. 50 Economy ticket for $324 per person are available. Travel duration is 5h 44m
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Alaska Airlines10h 52m06:44 AMSt. Louis Lambert AirportSt. Louis Lambert Airport6:36 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Alaska Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/4/2025 6:44:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/4/2025 6:36:00 PM. 50 Economy ticket for $497 per person are available. Travel duration is 10h 52m
Fastest Flights Friday
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Greyhound US13h 55m01:55 PMSt. Louis, MOGateway Station3:50 AMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/5/2025 1:55:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/6/2025 3:50:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 13h 55m
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Greyhound US15h 10m02:30 AMSt. Louis, MOGateway Station5:40 PMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/5/2025 2:30:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/5/2025 5:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 10m
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Greyhound US15h 35m08:45 AMSt. Louis, MOGateway Station12:20 AMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/5/2025 8:45:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/6/2025 12:20:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 35m
Fastest Buses Saturday
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United Airlines4h 14m08:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:14 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/7/2025 8:00:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/7/2025 1:14:00 PM. 50 Economy ticket for $359 per person are available. Travel duration is 4h 14m
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Skyscanner4h 35m08:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport2:00 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/7/2025 8:25:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/7/2025 2:00:00 PM. 50 Economy ticket for $359 per person are available. Travel duration is 4h 35m
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Skyscanner4h 49m09:39 AMSt. Louis Lambert AirportSt. Louis Lambert Airport3:28 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/7/2025 9:39:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/7/2025 3:28:00 PM. 50 Economy ticket for $359 per person are available. Travel duration is 4h 49m
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United Airlines5h 44m06:30 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:14 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/7/2025 6:30:00 AM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/7/2025 1:14:00 PM. 50 Economy ticket for $359 per person are available. Travel duration is 5h 44m
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Alaska Airlines26h 25m03:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport6:36 PMPittsburgh AirportPittsburgh Airport0EconomyA Flight from Alaska Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 4/7/2025 3:11:00 PM to Pittsburgh Airport, Pittsburgh Airport (USA) arriving at 4/8/2025 6:36:00 PM. 50 Economy ticket for $528 per person are available. Travel duration is 26h 25m
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Greyhound US13h 55m01:55 PMSt. Louis, MOGateway Station3:50 AMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/7/2025 1:55:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/8/2025 3:50:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 13h 55m
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Greyhound US15h 10m02:30 AMSt. Louis, MOGateway Station5:40 PMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/7/2025 2:30:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/7/2025 5:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 10m
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Greyhound US15h 35m08:45 AMSt. Louis, MOGateway Station12:20 AMPittsburghGrant Street Transportation Center0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 4/7/2025 8:45:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/8/2025 12:20:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 35m
Fastest Flights Monday
Fastest Buses Monday
Here you will find all operators and timetables for a
Bus from St. Louis, MO to Pittsburgh
What are the most popular stations in St. Louis, MO and Pittsburgh?
In St. Louis, MO, you will usually depart from Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, while in Pittsburgh you will be arriving at David L. Lawrence Convention Center, Central Station or University of, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Pittsburgh from St. Louis, MO? With 6 connections between 1 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between St. Louis, MO and Pittsburgh, you can pay as low as $75 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to Pittsburgh in just 4h 14m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting St. Louis, MO and Pittsburgh are Greyhound US, United Airlines and Skyscanner, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in St. Louis, MO and Pittsburgh is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Sauget, IL or to Green Tree, PA, and look at flights from St. Louis Lambert Airport, and landing at Pittsburgh Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from St. Louis, MO to Pittsburgh?
The most popular companies between St. Louis, MO and Pittsburgh, are Greyhound US, United Airlines and Skyscanner. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US
Airlines: United Airlines, Skyscanner and Alaska Airlines
All you need to know when you travel from St. Louis, MO to Pittsburgh
Check all information on comfort and services on all modes of transports from St. Louis, MO to Pittsburgh. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from St. Louis, MO to Pittsburgh
How can I reach Pittsburgh from St. Louis, MO?
Every day, there are on average 6 connections between Bus and Flight, with which you can get to Pittsburgh from St. Louis, MO.
How far is Pittsburgh from St. Louis, MO?
The distance between St. Louis, MO and Pittsburgh is 558.2 miles.
What is the most ecofriendly mode of transport between St. Louis, MO and Pittsburgh?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 24 kgs of CO2, a train 31 kgs, a car 153 kgs, and a flight 221 kgs.
What is the cheapest mode of transport from St. Louis, MO to Pittsburgh?
You can get to Pittsburgh with just $75 by taking a Bus from Greyhound US.
What is the fastest way to get from St. Louis, MO to Pittsburgh?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Pittsburgh in just 4h 14m with a Flight from United Airlines.
More routes to St. Louis, MO and to Pittsburgh
Looking for more options? Here you can see the most popular routes to St. Louis, MO and to Pittsburgh. Simply click on a connection, and you’ll find all the details about the route!
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