Bus Jacksonville, FL to St. Louis, MO: Compare prices and save money

Compare all timetables for the bus from Jacksonville, FL to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Jacksonville, FL to St. Louis, MO from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

Thursday

from $124

Friday

from $116

Saturday

Sunday

Monday

Cheapest bus trips Thursday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	33h 5m	9:45 PM	Jacksonville, FL	Amtrak Train Station	6:50 AM	St. Louis, MO	Gateway Station	Economy	$124	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/31/2025 9:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/2/2025 6:50:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 33h 5m
Greyhound US	21h 15m	9:35 AM	Jacksonville, FL	Amtrak Train Station	6:50 AM	St. Louis, MO	Gateway Station	Economy	$125	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/31/2025 9:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2025 6:50:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 21h 15m
FlixBus	18h 30m	9:25 PM	Jacksonville, FL	Amtrak Train Station	3:55 PM	St. Louis, MO	Gateway Station	Economy	$130	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/31/2025 9:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2025 3:55:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 18h 30m

Did you know that if you travel from Jacksonville, FL to St. Louis, MO via Atlanta, GA, you can save more than $18? You can find the corresponding connections below.
- FlixBus
  
  24h 35m
  
  0
  
  9:25 PM
  
  Jacksonville, FL
  Amtrak Train Station
  
  4:15 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $53
  
  A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/31/2025 9:25:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 8/1/2025 4:15:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 6h 50m
- Busbud
  
  10h 0m
  
  0
  
  12:00 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  10:00 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $53
  
  A Bus from Busbud goes from Garnett Transit Station, Atlanta, GA (USA) at 8/1/2025 12:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2025 10:00:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 10h 0m
Travel time is 6h 5m longer, but you will save $18

Cheapest bus trips Friday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	33h 5m	9:45 PM	Jacksonville, FL	Amtrak Train Station	6:50 AM	St. Louis, MO	Gateway Station	Economy	$116	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 8/1/2025 9:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/3/2025 6:50:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 33h 5m
Greyhound US	21h 15m	9:35 AM	Jacksonville, FL	Amtrak Train Station	6:50 AM	St. Louis, MO	Gateway Station	Economy	$118	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 8/1/2025 9:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/2/2025 6:50:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 21h 15m
FlixBus	18h 30m	9:25 PM	Jacksonville, FL	Amtrak Train Station	3:55 PM	St. Louis, MO	Gateway Station	Economy	$133	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 8/1/2025 9:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/2/2025 3:55:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 18h 30m

Frequency of bus connections between Jacksonville, FL and St. Louis, MO

See here how frequent the connections between Jacksonville, FL and St. Louis, MO are, during different times and days of the week.

Thursday is the busiest day, with more than 3 daily buses from Jacksonville, FL to St. Louis, MO. Thursday has instead the fewest connections, with only 3 daily coaches between Jacksonville, FL and St. Louis, MO.

The busiest time of the day is the Evening, with 4 buses from Jacksonville, FL to St. Louis, MO, while Morning sees the fewest connections between Jacksonville, FL and St. Louis, MO, with 2 offers.

Facts about the bus from Jacksonville, FL to St. Louis, MO

Compare all providers like FlixBus and Greyhound US that travel 3 times every day by bus from Jacksonville, FL to St. Louis, MO in one click! Book your bus ticket from Jacksonville, FL to St. Louis, MO starting from $116!

Cheapest Bus	$116
Fastest Bus	18h 30m
Earliest Bus	9:35 AM
Latest Bus	9:45 PM
Daily Bus Routes	3 Ø
Distance	750.9 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Jacksonville, FL to St. Louis, MO

Every day, 3 buses from 2 bus companies leave Jacksonville, FL for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/29/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/27

Monday 07/28

Tuesday 07/29

Wednesday 07/30

Thursday 07/31

$124

Friday 08/01

$116

Saturday 08/02

Sunday 08/03

Monday 08/04

Tuesday 08/05

Wednesday 08/06

Thursday 08/07

Friday 08/08

Saturday 08/09

Sunday 08/10

Monday 08/11

Tuesday 08/12

Wednesday 08/13

Thursday 08/14

Friday 08/15

Saturday 08/16

Sunday 08/17

Monday 08/18

Tuesday 08/19

Wednesday 08/20

Thursday 08/21

Friday 08/22

Saturday 08/23

The cheapest time to travel from Jacksonville, FL to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Jacksonville, FL to St. Louis, MO, for the next 30 days.

With a price starting from $116, Friday is the cheapest day for a bus from Jacksonville, FL to St. Louis, MO. Thursday instead is the most expensive day with prices starting from $124.

Evening is the cheapest day time for bus tickets from Jacksonville, FL to St. Louis, MO, with $116. Morning is the most expensive time of the day with prices starting from $118.

How to save money travelling from Jacksonville, FL to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Jacksonville, FL to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Jacksonville, FL to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Jacksonville, FL to St. Louis, MO are also emptier.

All bus stations and stops in Jacksonville, FL and St. Louis, MO

In the map below, you can see where to find all bus stations in Jacksonville, FL and St. Louis, MO.

Downtown Bus Stop

West Forsyth Street 1111

Beaver St. & Ocean St. Bus Stop

Central Bus Station

Old St. Augustine Rd

Old St. Augustine Rd 10584-13

Friendship Fountain

Lindbergh @ Hackberry NB Bus Stop

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Gateway Station

S 15th St 430

Service and Comfort on the bus from Jacksonville, FL to St. Louis, MO

Want to know which seat classes are available on the buses from Jacksonville, FL to St. Louis, MO? Or which bus companies serve the route Jacksonville, FL to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Jacksonville, FL to St. Louis, MO bus

How much does a Jacksonville, FL St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $116 and takes 33h 5m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Jacksonville, FL to St. Louis, MO?

This route is offered by 2 companies with a range of ticket prices between $116 and $133. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Jacksonville, FL to St. Louis, MO each day?

Every day, the Jacksonville, FL to St. Louis, MO bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Jacksonville, FL to St. Louis, MO take?

The fastest bus from Jacksonville, FL to St. Louis, MO is offered by FlixBus and takes 18h 30m. Bus tickets for this connection cost $130. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Jacksonville, FL to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Jacksonville, FL starts at 9:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Jacksonville, FL to St. Louis, MO?

The latest bus trip departing from Jacksonville, FL for St. Louis, MO starts at 9:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Jacksonville, FL St. Louis, MO route?

When traveling by bus from Jacksonville, FL to St. Louis, MO, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Jacksonville, FL and St. Louis, MO?

You can check all the direct connections between Jacksonville, FL and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Jacksonville, FL to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Jacksonville, FL St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Jacksonville, FL St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Jacksonville, FL to St. Louis, MO on your planned travel date.

Available seat classes which are offered on the bus route Jacksonville, FL to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Jacksonville, FL and to St. Louis, MO

Here’s an overview of the most popular bus routes to Jacksonville, FL and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!