Bus San Antonio, TX to St. Louis, MO: Compare prices and save money

Compare all timetables for the bus from San Antonio, TX to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to St. Louis, MO from various bus operators like Greyhound Lines Mexico, FlixBus or Greyhound US for the next days.

today

from $113

tomorrow

Tuesday

from $108

Wednesday

Thursday

from $115

Friday

Saturday

from $168

Cheapest bus trips today

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	21h 10m	1:30 AM	San Antonio, TX	Bus Station	10:40 PM	St. Louis, MO	Gateway Station	Economy	$113	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 7/27/2025 1:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/27/2025 10:40:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 21h 10m
Greyhound Lines Mexico	20h 15m	6:05 AM	San Antonio, TX	Bus Station	2:20 AM	St. Louis, MO	Gateway Station	Economy	$113	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 7/27/2025 6:05:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2025 2:20:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 20h 15m
FlixBus	25h 40m	9:00 PM	San Antonio, TX	Bus Station	10:40 PM	St. Louis, MO	Gateway Station	Economy	$117	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 7/27/2025 9:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2025 10:40:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 25h 40m
FlixBus	23h 35m	7:30 AM	San Antonio, TX	Bus Station	7:05 AM	St. Louis, MO	Gateway Station	Economy	$118	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 7/27/2025 7:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2025 7:05:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 23h 35m
Greyhound US	24h 15m	12:40 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$130	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/27/2025 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2025 12:55:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 24h 15m

Cheapest bus trips Tuesday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	27h 25m	7:15 PM	San Antonio, TX	Bus Station	10:40 PM	St. Louis, MO	Gateway Station	Economy	$108	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 7/29/2025 7:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/30/2025 10:40:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 27h 25m
Greyhound Lines Mexico	21h 10m	1:30 AM	San Antonio, TX	Bus Station	10:40 PM	St. Louis, MO	Gateway Station	Economy	$123	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 7/29/2025 1:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/29/2025 10:40:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 21h 10m
Greyhound US	24h 15m	12:40 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$145	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/29/2025 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/30/2025 12:55:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 24h 15m

Cheapest bus trips Thursday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	25h 0m	6:05 AM	San Antonio, TX	Bus Station	7:05 AM	St. Louis, MO	Gateway Station	Economy	$115	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 7/31/2025 6:05:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2025 7:05:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 25h 0m
Greyhound Lines Mexico	25h 0m	6:05 AM	San Antonio, TX	Bus Station	7:05 AM	St. Louis, MO	Gateway Station	Economy	$119	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 7/31/2025 6:05:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2025 7:05:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 25h 0m
Greyhound US	24h 15m	12:40 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$123	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/31/2025 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2025 12:55:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 24h 15m
Greyhound US	24h 15m	12:40 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$127	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 7/31/2025 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2025 12:55:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 24h 15m
Valley Transit	25h 40m	9:00 PM	San Antonio, TX	Bus Station	10:40 PM	St. Louis, MO	Gateway Station	Economy	$128	A Bus from Valley Transit goes from Bus Station, San Antonio, TX (USA) at 7/31/2025 9:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2025 10:40:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 25h 40m

Cheapest bus trips Saturday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	25h 40m	9:00 PM	San Antonio, TX	Bus Station	10:40 PM	St. Louis, MO	Gateway Station	Economy	$168	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 8/2/2025 9:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/3/2025 10:40:00 PM. 50 Economy ticket for $168 per person are available. Travel duration is 25h 40m
Greyhound Lines Mexico	21h 10m	1:30 AM	San Antonio, TX	Bus Station	10:40 PM	St. Louis, MO	Gateway Station	Economy	$176	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 8/2/2025 1:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/2/2025 10:40:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 21h 10m
Greyhound US	24h 15m	12:40 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$182	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 8/2/2025 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/3/2025 12:55:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 24h 15m
Greyhound Lines Mexico	25h 0m	6:05 AM	San Antonio, TX	Bus Station	7:05 AM	St. Louis, MO	Gateway Station	Economy	$196	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 8/2/2025 6:05:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/3/2025 7:05:00 AM. 50 Economy ticket for $196 per person are available. Travel duration is 25h 0m

Did you know that if you travel from San Antonio, TX to St. Louis, MO via Dallas, you can save more than $55? You can find the corresponding connections below.
- Busbud
  
  20h 40m
  
  0
  
  1:30 AM
  
  San Antonio, TX
  Bus Station
  
  6:25 AM
  
  Dallas
  Bus Station
  
  0
  
  Economy
  
  $33
  
  A Bus from Busbud goes from Bus Station, San Antonio, TX (USA) at 7/30/2025 1:30:00 AM to Bus Station, Dallas (USA) arriving at 7/30/2025 6:25:00 AM. 50 Economy ticket for $33 per person are available. Travel duration is 4h 55m
- Busbud
  
  14h 50m
  
  0
  
  7:20 AM
  
  Dallas
  Bus Station
  
  10:10 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $80
  
  A Bus from Busbud goes from Bus Station, Dallas (USA) at 7/30/2025 7:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/30/2025 10:10:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 14h 50m
Travel Time is 0h 30m shorter, and you will save $55

Frequency of bus connections between San Antonio, TX and St. Louis, MO

See here how frequent the connections between San Antonio, TX and St. Louis, MO are, during different times and days of the week.

Thursday is the busiest day, with more than 8 daily buses from San Antonio, TX to St. Louis, MO. Tuesday has instead the fewest connections, with only 3 daily coaches between San Antonio, TX and St. Louis, MO.

The busiest time of the day is the Morning, with 6 buses from San Antonio, TX to St. Louis, MO, while Afternoon sees the fewest connections between San Antonio, TX and St. Louis, MO, with 5 offers.

Facts about the bus from San Antonio, TX to St. Louis, MO

Compare all providers like Greyhound Lines Mexico, FlixBus and Greyhound US that travel 5 times every day by bus from San Antonio, TX to St. Louis, MO in one click! Book your bus ticket from San Antonio, TX to St. Louis, MO starting from $108!

Cheapest Bus	$108
Fastest Bus	20h 15m
Earliest Bus	1:30 AM
Latest Bus	9:00 PM
Daily Bus Routes	5 Ø
Distance	792.3 miles
Bus Companies	Greyhound Lines Mexico, FlixBus, Greyhound US and Valley Transit

Cheapest bus connections from San Antonio, TX to St. Louis, MO

Every day, 5 buses from 4 bus companies leave San Antonio, TX for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/27/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/27

$113

Monday 07/28

Tuesday 07/29

$108

Wednesday 07/30

Thursday 07/31

$115

Friday 08/01

Saturday 08/02

$168

Sunday 08/03

Monday 08/04

$152

Tuesday 08/05

Wednesday 08/06

Thursday 08/07

$118

Friday 08/08

Saturday 08/09

$118

Sunday 08/10

Monday 08/11

$112

Tuesday 08/12

Wednesday 08/13

Thursday 08/14

$111

Friday 08/15

Saturday 08/16

Sunday 08/17

Monday 08/18

$110

Tuesday 08/19

Wednesday 08/20

Thursday 08/21

Friday 08/22

Saturday 08/23

The cheapest time to travel from San Antonio, TX to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to St. Louis, MO, for the next 30 days.

With a price starting from $108, Tuesday is the cheapest day for a bus from San Antonio, TX to St. Louis, MO. Saturday instead is the most expensive day with prices starting from $168.

Evening is the cheapest day time for bus tickets from San Antonio, TX to St. Louis, MO, with $108. Afternoon is the most expensive time of the day with prices starting from $123.

How to save money travelling from San Antonio, TX to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to St. Louis, MO are also emptier.

All bus stations and stops in San Antonio, TX and St. Louis, MO

In the map below, you can see where to find all bus stations in San Antonio, TX and St. Louis, MO.

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Central Station

Urban Loop

Gateway Station

S 15th St 430

Lindbergh @ Hackberry NB Bus Stop

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Service and Comfort on the bus from San Antonio, TX to St. Louis, MO

Want to know which seat classes are available on the buses from San Antonio, TX to St. Louis, MO? Or which bus companies serve the route San Antonio, TX to St. Louis, MO? Below you will find answers to your questions.

FAQs about the San Antonio, TX to St. Louis, MO bus

How much does a San Antonio, TX St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $108 and takes 27h 25m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to St. Louis, MO?

This route is offered by 4 companies with a range of ticket prices between $108 and $196. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from San Antonio, TX to St. Louis, MO each day?

Every day, the San Antonio, TX to St. Louis, MO bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to St. Louis, MO take?

The fastest bus from San Antonio, TX to St. Louis, MO is offered by Greyhound Lines Mexico and takes 20h 15m. Bus tickets for this connection cost $113. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from San Antonio, TX starts at 1:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to St. Louis, MO?

The latest bus trip departing from San Antonio, TX for St. Louis, MO starts at 9:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX St. Louis, MO route?

When traveling by bus from San Antonio, TX to St. Louis, MO, passengers can travel with Greyhound Lines Mexico, FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and St. Louis, MO?

You can check all the direct connections between San Antonio, TX and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound Lines Mexico, FlixBus and Greyhound US.

What can I take with me on the San Antonio, TX to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to St. Louis, MO on your planned travel date.

Available seat classes which are offered on the bus route San Antonio, TX to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to St. Louis, MO

Here’s an overview of the most popular bus routes to San Antonio, TX and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!