What is the best way to travel from Indianapolis to San Diego?
Looking for a trip? Compare all the available Buses and Flights for the journey to San Diego from Indianapolis. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach San Diego from Indianapolis?
You can get to San Diego with just $159 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus61h 35m011:30 PMIndianapolisWashington / Delaware10:05 AMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/5/2025 11:30:00 PM to Seaport Village, San Diego (USA) arriving at 12/8/2025 10:05:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 61h 35m
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Greyhound US64h 55m08:10 PMIndianapolisCentral Bus Station10:05 AMSan DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/5/2025 8:10:00 PM to Seaport Village, San Diego (USA) arriving at 12/8/2025 10:05:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 64h 55m
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FlixBus65h 40m011:30 PMIndianapolisWashington / Delaware2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/5/2025 11:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/8/2025 2:10:00 PM. 50 Economy ticket for $226 per person are available. Travel duration is 65h 40m
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FlixBus61h 10m011:30 PMIndianapolisWashington / Delaware9:40 AMSan DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/5/2025 11:30:00 PM to La Jolla Village, San Diego (USA) arriving at 12/8/2025 9:40:00 AM. 50 Economy ticket for $226 per person are available. Travel duration is 61h 10m
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Greyhound US54h 15m011:25 AMIndianapolisCentral Bus Station2:40 PMSan DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/5/2025 11:25:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 12/7/2025 2:40:00 PM. 50 Economy ticket for $239 per person are available. Travel duration is 54h 15m
Cheapest Buses Friday
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Greyhound US53h 15m011:25 AMIndianapolisCentral Bus Station1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/6/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/8/2025 1:40:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 53h 15m
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Greyhound US53h 45m011:25 AMIndianapolisCentral Bus Station2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/6/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/8/2025 2:10:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 53h 45m
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FlixBus63h 15m011:30 PMIndianapolisWashington / Delaware11:45 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/6/2025 11:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/9/2025 11:45:00 AM. 50 Economy ticket for $176 per person are available. Travel duration is 63h 15m
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FlixBus69h 40m011:30 PMIndianapolisWashington / Delaware6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/6/2025 11:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/9/2025 6:10:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 69h 40m
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FlixBus69h 5m011:30 PMIndianapolisWashington / Delaware5:35 PMSan DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/6/2025 11:30:00 PM to La Jolla Village, San Diego (USA) arriving at 12/9/2025 5:35:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 69h 5m
Cheapest Buses Saturday
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Frontier Airlines6h 11m08:48 PMIndianapolis AirportIndianapolis Airport11:59 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 8:48:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/7/2025 11:59:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 6h 11m
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United Airlines8h 53m05:45 AMIndianapolis AirportIndianapolis Airport11:38 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/7/2025 11:38:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 8h 53m
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Alaska Airlines7h 37m06:45 AMIndianapolis AirportIndianapolis Airport11:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 6:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/7/2025 11:22:00 AM. 50 Economy ticket for $323 per person are available. Travel duration is 7h 37m
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American Airlines6h 57m011:53 AMIndianapolis AirportIndianapolis Airport3:50 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 11:53:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/7/2025 3:50:00 PM. 50 Economy ticket for $479 per person are available. Travel duration is 6h 57m
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Spirit Airlines13h 2m08:48 AMIndianapolis AirportIndianapolis Airport6:50 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 8:48:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/7/2025 6:50:00 PM. 50 Economy ticket for $519 per person are available. Travel duration is 13h 2m
Cheapest Flights Sunday
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Frontier Airlines23h 42m09:11 PMIndianapolis AirportIndianapolis Airport5:53 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 9:11:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/9/2025 5:53:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 23h 42m
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Spirit Airlines18h 11m08:48 AMIndianapolis AirportIndianapolis Airport11:59 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 8:48:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/8/2025 11:59:00 PM. 50 Economy ticket for $167 per person are available. Travel duration is 18h 11m
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Allegiant Air7h 38m08:00 AMIndianapolis AirportIndianapolis Airport12:38 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 8:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/8/2025 12:38:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 7h 38m
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United Airlines8h 53m05:45 AMIndianapolis AirportIndianapolis Airport11:38 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/8/2025 11:38:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 8h 53m
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Alaska Airlines17h 43m07:30 PMIndianapolis AirportIndianapolis Airport10:13 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 7:30:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/9/2025 10:13:00 AM. 50 Economy ticket for $235 per person are available. Travel duration is 17h 43m
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FlixBus63h 50m011:30 PMIndianapolisWashington / Delaware12:20 PMSan DiegoSan Ysidro Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/8/2025 11:30:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/11/2025 12:20:00 PM. 50 Economy ticket for $289 per person are available. Travel duration is 63h 50m
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FlixBus60h 15m09:30 AMIndianapolisWashington / Delaware6:45 PMSan DiegoSan Ysidro Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/8/2025 9:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 12/10/2025 6:45:00 PM. 50 Economy ticket for $292 per person are available. Travel duration is 60h 15m
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Greyhound US49h 40m08:05 PMIndianapolisCentral Bus Station6:45 PMSan DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/8/2025 8:05:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/10/2025 6:45:00 PM. 50 Economy ticket for $292 per person are available. Travel duration is 49h 40m
Cheapest Flights Monday
Cheapest Buses Monday
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FlixBus64h 40m08:35 AMIndianapolisWashington / Delaware10:15 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/10/2025 8:35:00 AM to Seaport Village, San Diego (USA) arriving at 12/12/2025 10:15:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 64h 40m
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FlixBus56h 35m08:35 AMIndianapolisWashington / Delaware2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/10/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 2:10:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 56h 35m
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FlixBus66h 15m08:35 AMIndianapolisWashington / Delaware11:50 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/10/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 11:50:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 66h 15m
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Greyhound US53h 45m011:25 AMIndianapolisCentral Bus Station2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/10/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 2:10:00 PM. 50 Economy ticket for $190 per person are available. Travel duration is 53h 45m
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Greyhound US53h 15m011:25 AMIndianapolisCentral Bus Station1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/10/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/12/2025 1:40:00 PM. 50 Economy ticket for $192 per person are available. Travel duration is 53h 15m
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Spirit Airlines38h 48m012:03 PMIndianapolis AirportIndianapolis Airport11:51 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 12:03:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/11/2025 11:51:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 38h 48m
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United Airlines8h 53m05:45 AMIndianapolis AirportIndianapolis Airport11:38 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/10/2025 11:38:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 8h 53m
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United Airlines6h 40m06:00 AMIndianapolis AirportIndianapolis Airport9:40 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/10/2025 9:40:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 6h 40m
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Alaska Airlines17h 43m07:30 PMIndianapolis AirportIndianapolis Airport10:13 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 7:30:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/11/2025 10:13:00 AM. 50 Economy ticket for $235 per person are available. Travel duration is 17h 43m
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American Airlines7h 28m05:26 AMIndianapolis AirportIndianapolis Airport9:54 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 5:26:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/10/2025 9:54:00 AM. 50 Economy ticket for $311 per person are available. Travel duration is 7h 28m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
What are the fastest trips from Indianapolis to San Diego?
You can get to San Diego from Indianapolis in just 6h 11m with a Flight from Frontier Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Greyhound US54h 15m011:25 AMIndianapolisCentral Bus Station2:40 PMSan DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/5/2025 11:25:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 12/7/2025 2:40:00 PM. 50 Economy ticket for $239 per person are available. Travel duration is 54h 15m
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FlixBus61h 10m011:30 PMIndianapolisWashington / Delaware9:40 AMSan DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/5/2025 11:30:00 PM to La Jolla Village, San Diego (USA) arriving at 12/8/2025 9:40:00 AM. 50 Economy ticket for $226 per person are available. Travel duration is 61h 10m
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FlixBus61h 35m011:30 PMIndianapolisWashington / Delaware10:05 AMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/5/2025 11:30:00 PM to Seaport Village, San Diego (USA) arriving at 12/8/2025 10:05:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 61h 35m
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Greyhound US64h 55m08:10 PMIndianapolisCentral Bus Station10:05 AMSan DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/5/2025 8:10:00 PM to Seaport Village, San Diego (USA) arriving at 12/8/2025 10:05:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 64h 55m
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FlixBus65h 40m011:30 PMIndianapolisWashington / Delaware2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/5/2025 11:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/8/2025 2:10:00 PM. 50 Economy ticket for $226 per person are available. Travel duration is 65h 40m
Fastest Buses Friday
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Greyhound US53h 15m011:25 AMIndianapolisCentral Bus Station1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/6/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/8/2025 1:40:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 53h 15m
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Greyhound US53h 45m011:25 AMIndianapolisCentral Bus Station2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/6/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/8/2025 2:10:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 53h 45m
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FlixBus63h 15m011:30 PMIndianapolisWashington / Delaware11:45 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/6/2025 11:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/9/2025 11:45:00 AM. 50 Economy ticket for $176 per person are available. Travel duration is 63h 15m
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FlixBus69h 5m011:30 PMIndianapolisWashington / Delaware5:35 PMSan DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/6/2025 11:30:00 PM to La Jolla Village, San Diego (USA) arriving at 12/9/2025 5:35:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 69h 5m
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FlixBus69h 40m011:30 PMIndianapolisWashington / Delaware6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/6/2025 11:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/9/2025 6:10:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 69h 40m
Fastest Buses Saturday
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Frontier Airlines6h 11m08:48 PMIndianapolis AirportIndianapolis Airport11:59 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 8:48:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/7/2025 11:59:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 6h 11m
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American Airlines6h 57m011:53 AMIndianapolis AirportIndianapolis Airport3:50 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 11:53:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/7/2025 3:50:00 PM. 50 Economy ticket for $479 per person are available. Travel duration is 6h 57m
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Alaska Airlines7h 37m06:45 AMIndianapolis AirportIndianapolis Airport11:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 6:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/7/2025 11:22:00 AM. 50 Economy ticket for $323 per person are available. Travel duration is 7h 37m
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United Airlines8h 53m05:45 AMIndianapolis AirportIndianapolis Airport11:38 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/7/2025 11:38:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 8h 53m
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Spirit Airlines13h 2m08:48 AMIndianapolis AirportIndianapolis Airport6:50 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 8:48:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/7/2025 6:50:00 PM. 50 Economy ticket for $519 per person are available. Travel duration is 13h 2m
Fastest Flights Sunday
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Allegiant Air7h 38m08:00 AMIndianapolis AirportIndianapolis Airport12:38 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 8:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/8/2025 12:38:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 7h 38m
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United Airlines8h 53m05:45 AMIndianapolis AirportIndianapolis Airport11:38 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/8/2025 11:38:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 8h 53m
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Alaska Airlines17h 43m07:30 PMIndianapolis AirportIndianapolis Airport10:13 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 7:30:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/9/2025 10:13:00 AM. 50 Economy ticket for $235 per person are available. Travel duration is 17h 43m
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Spirit Airlines18h 11m08:48 AMIndianapolis AirportIndianapolis Airport11:59 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 8:48:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/8/2025 11:59:00 PM. 50 Economy ticket for $167 per person are available. Travel duration is 18h 11m
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Frontier Airlines23h 42m09:11 PMIndianapolis AirportIndianapolis Airport5:53 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 9:11:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/9/2025 5:53:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 23h 42m
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Greyhound US49h 40m08:05 PMIndianapolisCentral Bus Station6:45 PMSan DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/8/2025 8:05:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/10/2025 6:45:00 PM. 50 Economy ticket for $292 per person are available. Travel duration is 49h 40m
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FlixBus60h 15m09:30 AMIndianapolisWashington / Delaware6:45 PMSan DiegoSan Ysidro Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/8/2025 9:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 12/10/2025 6:45:00 PM. 50 Economy ticket for $292 per person are available. Travel duration is 60h 15m
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FlixBus63h 50m011:30 PMIndianapolisWashington / Delaware12:20 PMSan DiegoSan Ysidro Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/8/2025 11:30:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/11/2025 12:20:00 PM. 50 Economy ticket for $289 per person are available. Travel duration is 63h 50m
Fastest Flights Monday
Fastest Buses Monday
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United Airlines6h 40m06:00 AMIndianapolis AirportIndianapolis Airport9:40 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/10/2025 9:40:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 6h 40m
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American Airlines7h 28m05:26 AMIndianapolis AirportIndianapolis Airport9:54 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 5:26:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/10/2025 9:54:00 AM. 50 Economy ticket for $311 per person are available. Travel duration is 7h 28m
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United Airlines8h 53m05:45 AMIndianapolis AirportIndianapolis Airport11:38 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/10/2025 11:38:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 8h 53m
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Alaska Airlines17h 43m07:30 PMIndianapolis AirportIndianapolis Airport10:13 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 7:30:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/11/2025 10:13:00 AM. 50 Economy ticket for $235 per person are available. Travel duration is 17h 43m
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Spirit Airlines38h 48m012:03 PMIndianapolis AirportIndianapolis Airport11:51 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 12:03:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/11/2025 11:51:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 38h 48m
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Greyhound US53h 15m011:25 AMIndianapolisCentral Bus Station1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/10/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/12/2025 1:40:00 PM. 50 Economy ticket for $192 per person are available. Travel duration is 53h 15m
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Greyhound US53h 45m011:25 AMIndianapolisCentral Bus Station2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/10/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 2:10:00 PM. 50 Economy ticket for $190 per person are available. Travel duration is 53h 45m
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FlixBus56h 35m08:35 AMIndianapolisWashington / Delaware2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/10/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 2:10:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 56h 35m
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FlixBus64h 40m08:35 AMIndianapolisWashington / Delaware10:15 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/10/2025 8:35:00 AM to Seaport Village, San Diego (USA) arriving at 12/12/2025 10:15:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 64h 40m
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FlixBus66h 15m08:35 AMIndianapolisWashington / Delaware11:50 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/10/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 11:50:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 66h 15m
Fastest Flights Wednesday
Fastest Buses Wednesday
Here you will find all operators and timetables for a
Bus from Indianapolis to San Diego
What are the most popular stations in Indianapolis and San Diego?
In Indianapolis, you will usually depart from Central Bus Station, Greyhound Bus Station or Downtown Transit Center, while in San Diego you will be arriving at San Ysidro Transit Center, University Av & Bancroft St Bus Stop or Old Town Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to San Diego from Indianapolis? With 6 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Indianapolis and San Diego, you can pay as low as $159 with a Flight from Frontier Airlines.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Frontier Airlines: you will get to San Diego in just 6h 11m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Indianapolis and San Diego are FlixBus, Greyhound US and United Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Indianapolis and San Diego is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Beech Grove, IN or to San Diego Airport, and look at flights from Indianapolis Airport, and landing at Tijuana Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Indianapolis to San Diego?
The most popular companies between Indianapolis and San Diego, are FlixBus, Greyhound US and United Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Greyhound US
Airlines: United Airlines, Alaska Airlines, Spirit Airlines and 3 more.
All you need to know when you travel from Indianapolis to San Diego
Check all information on comfort and services on all modes of transports from Indianapolis to San Diego. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Indianapolis to San Diego
How can I reach San Diego from Indianapolis?
Every day, there are on average 6 connections between Bus and Flight, with which you can get to San Diego from Indianapolis.
How far is San Diego from Indianapolis?
The distance between Indianapolis and San Diego is 1,785.2 miles.
What is the most ecofriendly mode of transport between Indianapolis and San Diego?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 78 kgs of CO2, a train 101 kgs, a car 488 kgs, and a flight 707 kgs.
What is the cheapest mode of transport from Indianapolis to San Diego?
You can get to San Diego with just $159 by taking a Flight from Frontier Airlines.
What is the fastest way to get from Indianapolis to San Diego?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Diego in just 6h 11m with a Flight from Frontier Airlines.
More routes to Indianapolis and to San Diego
Looking for more options? Here you can see the most popular routes to Indianapolis and to San Diego. Simply click on a connection, and you’ll find all the details about the route!

