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How to get from La Serena to Santiago, RM

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What is the best way to travel from La Serena to Santiago, RM?

Looking for a trip? Compare all the available Buses and Flights for the journey to Santiago, RM from La Serena. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 12 available companies to find your perfect trip!
Bus is the cheapest, while Flight is the fastest way on this route
Transport type
Travel time
Cheapest price
Average price
Daily departures
Bus
5h 40m
$7
$11
251
Flight
0h 56m
$27
$65
9

What is the cheapest way to reach Santiago, RM from La Serena?

You can get to Santiago, RM with just $7 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.

today
from $8
tomorrow
from $8
Saturday
from $7
Sunday
from $8
Monday
from $7
Tuesday
from $7
Wednesday
from $7

    Cheapest Buses today

  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $8
  • Cikbus Elité
    5h 40m
    0
    5:20 PM
    La Serena
    Bus Stop
    11:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9
  • Pluss Chile
    6h 40m
    0
    12:05 AM
    La Serena
    Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Economy
    $10
  • Condor Bus
    6h 15m
    0
    1:45 AM
    La Serena
    Bus Station
    8:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Economy
    $12
  • Nueva Andimar Vip
    6h 10m
    0
    8:00 AM
    La Serena
    Bus Stop
    2:10 PM
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    $13
  • Cheapest Flights today

  • LAN Perú
    0h 57m
    0
    12:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:32 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $99
  • LAN Perú
    0h 57m
    0
    9:45 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:42 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $114
  • Sky Airline
    0h 58m
    0
    10:42 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:40 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $118
  • LAN Airlines
    0h 58m
    0
    2:46 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    3:44 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $140
  • Sky Airline
    0h 58m
    0
    4:07 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    5:05 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $168

    Cheapest Buses tomorrow

  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $8
  • Buses Romani
    6h 30m
    0
    12:05 AM
    La Serena
    Bus Station
    6:35 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Economy
    $8
  • Cikbus Elité
    5h 40m
    0
    5:20 PM
    La Serena
    Bus Stop
    11:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9
  • Pluss Chile
    6h 30m
    0
    2:30 AM
    La Serena
    Bus Station
    9:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Economy
    $10
  • Nueva Andimar Vip
    6h 10m
    0
    8:00 AM
    La Serena
    Bus Station
    2:10 PM
    Santiago, RM
    Sur Bus Station
    0
    Nueva Andimar Vip
    First Class
    $12
  • Cheapest Flights tomorrow

  • JetSmart
    0h 58m
    0
    9:18 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:16 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $59
  • LAN Perú
    0h 57m
    0
    1:20 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:17 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $71
  • LAN Perú
    0h 57m
    0
    11:08 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:05 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $84
  • Sky Airline
    0h 58m
    0
    11:19 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:17 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $89
  • Sky Airline
    0h 58m
    0
    3:54 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:52 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $134

    Cheapest Buses Saturday

  • FlixBus
    6h 5m
    0
    5:45 PM
    La Serena
    Bus Station
    11:50 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $7
  • Pluss Chile
    6h 30m
    0
    2:30 AM
    La Serena
    Bus Station
    9:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Economy
    $10
  • Cikbus Elité
    6h 30m
    0
    2:00 AM
    La Serena
    Bus Station
    8:30 AM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Economy
    $11
  • Condor Bus
    6h 5m
    0
    4:35 PM
    La Serena
    Bus Station
    10:40 PM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Economy
    $12
  • Buses Romani
    6h 15m
    0
    12:30 AM
    La Serena
    Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    First Class
    $16
  • Cheapest Flights Saturday

  • LAN Airlines
    0h 58m
    0
    6:59 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    7:57 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $27
  • JetSmart
    0h 58m
    0
    5:56 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    6:54 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $32
  • Sky Airline
    0h 58m
    0
    4:27 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    5:25 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $47
  • LAN Airlines
    0h 58m
    0
    2:56 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    3:54 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $62
  • LAN Perú
    0h 58m
    0
    7:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:43 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $84

    Cheapest Buses Sunday

  • FlixBus
    6h 5m
    0
    12:05 AM
    La Serena
    Bus Station
    6:10 AM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $8
  • Nueva Andimar Vip
    6h 10m
    0
    8:00 AM
    La Serena
    Bus Station
    2:10 PM
    Santiago, RM
    Sur Bus Station
    0
    Nueva Andimar Vip
    First Class
    $12
  • Condor Bus
    6h 15m
    0
    1:45 AM
    La Serena
    Bus Station
    8:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Economy
    $12
  • Serena Mar
    6h 0m
    0
    10:00 AM
    La Serena
    Bus Station
    4:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • Cikbus Elité
    7h 0m
    0
    6:00 AM
    La Serena
    Bus Station
    1:00 PM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Economy
    $14
  • Cheapest Flights Sunday

  • LAN Perú
    0h 57m
    0
    1:24 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:21 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $42
  • JetSmart
    0h 58m
    0
    2:18 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    3:16 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $46
  • LAN Perú
    0h 57m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:37 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $54
  • Sky Airline
    0h 58m
    0
    1:25 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:23 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $65
  • LAN Airlines
    0h 57m
    0
    10:22 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:19 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $71

    Cheapest Buses Monday

  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $7
  • Buses Romani
    6h 30m
    0
    12:05 AM
    La Serena
    Bus Station
    6:35 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Economy
    $8
  • Nueva Andimar Vip
    6h 10m
    0
    9:00 AM
    La Serena
    Bus Station
    3:10 PM
    Santiago, RM
    Sur Bus Station
    0
    Nueva Andimar Vip
    Economy
    $12
  • Condor Bus
    6h 5m
    0
    4:35 PM
    La Serena
    Bus Station
    10:40 PM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Economy
    $12
  • Cikbus Elité
    5h 55m
    0
    1:35 AM
    La Serena
    Bus Station
    7:30 AM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Economy
    $14
  • Cheapest Flights Monday

  • JetSmart
    0h 58m
    0
    7:25 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:23 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $32
  • Sky Airline
    0h 58m
    0
    10:17 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:15 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $33
  • Sky Airline
    0h 58m
    0
    11:32 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:30 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $33
  • LAN Airlines
    0h 58m
    0
    7:11 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:09 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $42
  • LAN Perú
    0h 58m
    0
    6:09 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    7:07 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $48

    Cheapest Buses Tuesday

  • FlixBus
    6h 5m
    0
    12:05 AM
    La Serena
    Bus Station
    6:10 AM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $7
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Bus Stop
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $11
  • Buses Paravias
    6h 40m
    0
    11:30 PM
    La Serena
    Bus Stop
    6:10 AM
    Santiago, RM
    Terminal San Borja
    0
    Buses Paravias
    Economy
    $14
  • Buses Romani
    6h 15m
    0
    12:30 AM
    La Serena
    Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    First Class
    $16
  • Pullman San Andres
    6h 10m
    0
    12:00 PM
    La Serena
    Bus Station
    6:10 PM
    Santiago, RM
    Terminal San Borja
    0
    Pullman San Andres
    Economy
    $16
  • Cheapest Flights Tuesday

  • Sky Airline
    0h 58m
    0
    9:47 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:45 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $44
  • JetSmart
    0h 58m
    0
    10:50 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:48 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $46
  • LAN Perú
    0h 57m
    0
    9:42 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:39 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $48
  • LAN Perú
    0h 56m
    0
    8:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    9:41 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $55

    Cheapest Buses Wednesday

  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $7
  • FlixBus
    6h 5m
    0
    7:00 AM
    La Serena
    Bus Station
    1:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $7
  • Cikbus Elité
    7h 15m
    0
    12:35 PM
    La Serena
    Bus Station
    7:50 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $11
  • Cikbus Elité
    6h 0m
    0
    5:00 PM
    La Serena
    Bus Station
    11:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $11
  • Buses Paravias
    6h 40m
    0
    11:30 PM
    La Serena
    Bus Station
    6:10 AM
    Santiago, RM
    Terminal San Borja
    0
    Buses Paravias
    First Class
    $14
  • Cheapest Flights Wednesday

  • Sky Airline
    0h 58m
    0
    9:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:33 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $33
  • JetSmart
    0h 58m
    0
    9:06 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:04 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $38
  • Air China Cargo
    0h 58m
    0
    9:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:33 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Air China Cargo
    Economy
    from $49
  • LAN Perú
    0h 58m
    0
    3:50 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:48 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $54
  • LAN Airlines
    0h 56m
    0
    9:20 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:16 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $54

What are the fastest trips from La Serena to Santiago, RM?

You can get to Santiago, RM from La Serena in just 0h 56m with a Flight from LAN Perú. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.

today
from 0h 57m
tomorrow
from 0h 57m
Saturday
from 0h 58m
Sunday
from 0h 57m
Monday
from 0h 58m
Tuesday
from 0h 56m
Wednesday
from 0h 56m

    Fastest Flights today

  • LAN Perú
    0h 57m
    0
    12:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:32 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $99
  • LAN Perú
    0h 57m
    0
    9:45 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:42 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $114
  • Sky Airline
    0h 58m
    0
    10:42 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:40 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $118
  • LAN Airlines
    0h 58m
    0
    2:46 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    3:44 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $140
  • Sky Airline
    0h 58m
    0
    4:07 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    5:05 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $168
  • Fastest Buses today

  • Cikbus Elité
    5h 40m
    0
    5:20 PM
    La Serena
    Bus Stop
    11:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9
  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $8
  • Nueva Andimar Vip
    6h 10m
    0
    8:00 AM
    La Serena
    Bus Stop
    2:10 PM
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    $13
  • Condor Bus
    6h 15m
    0
    1:45 AM
    La Serena
    Bus Station
    8:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Economy
    $12
  • Pluss Chile
    6h 40m
    0
    12:05 AM
    La Serena
    Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Economy
    $10

    Fastest Flights tomorrow

  • LAN Perú
    0h 57m
    0
    1:20 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:17 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $71
  • LAN Perú
    0h 57m
    0
    11:08 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:05 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $84
  • JetSmart
    0h 58m
    0
    9:18 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:16 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $59
  • Sky Airline
    0h 58m
    0
    11:19 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:17 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $89
  • Sky Airline
    0h 58m
    0
    3:54 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:52 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $134
  • Fastest Buses tomorrow

  • Cikbus Elité
    5h 40m
    0
    5:20 PM
    La Serena
    Bus Stop
    11:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9
  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $8
  • Nueva Andimar Vip
    6h 10m
    0
    8:00 AM
    La Serena
    Bus Station
    2:10 PM
    Santiago, RM
    Sur Bus Station
    0
    Nueva Andimar Vip
    First Class
    $12
  • Buses Romani
    6h 30m
    0
    12:05 AM
    La Serena
    Bus Station
    6:35 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Economy
    $8
  • Pluss Chile
    6h 30m
    0
    2:30 AM
    La Serena
    Bus Station
    9:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Economy
    $10

    Fastest Flights Saturday

  • LAN Airlines
    0h 58m
    0
    6:59 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    7:57 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $27
  • JetSmart
    0h 58m
    0
    5:56 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    6:54 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $32
  • Sky Airline
    0h 58m
    0
    4:27 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    5:25 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $47
  • LAN Airlines
    0h 58m
    0
    2:56 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    3:54 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $62
  • LAN Perú
    0h 58m
    0
    7:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:43 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $84
  • Fastest Buses Saturday

  • FlixBus
    6h 5m
    0
    5:45 PM
    La Serena
    Bus Station
    11:50 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $7
  • Condor Bus
    6h 5m
    0
    4:35 PM
    La Serena
    Bus Station
    10:40 PM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Economy
    $12
  • Buses Romani
    6h 15m
    0
    12:30 AM
    La Serena
    Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    First Class
    $16
  • Pluss Chile
    6h 30m
    0
    2:30 AM
    La Serena
    Bus Station
    9:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Economy
    $10
  • Cikbus Elité
    6h 30m
    0
    2:00 AM
    La Serena
    Bus Station
    8:30 AM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Economy
    $11

    Fastest Flights Sunday

  • LAN Perú
    0h 57m
    0
    1:24 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:21 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $42
  • LAN Perú
    0h 57m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:37 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $54
  • LAN Airlines
    0h 57m
    0
    10:22 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:19 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $71
  • JetSmart
    0h 58m
    0
    2:18 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    3:16 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $46
  • Sky Airline
    0h 58m
    0
    1:25 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:23 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $65
  • Fastest Buses Sunday

  • Serena Mar
    6h 0m
    0
    10:00 AM
    La Serena
    Bus Station
    4:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • FlixBus
    6h 5m
    0
    12:05 AM
    La Serena
    Bus Station
    6:10 AM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $8
  • Nueva Andimar Vip
    6h 10m
    0
    8:00 AM
    La Serena
    Bus Station
    2:10 PM
    Santiago, RM
    Sur Bus Station
    0
    Nueva Andimar Vip
    First Class
    $12
  • Condor Bus
    6h 15m
    0
    1:45 AM
    La Serena
    Bus Station
    8:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Economy
    $12
  • Cikbus Elité
    7h 0m
    0
    6:00 AM
    La Serena
    Bus Station
    1:00 PM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Economy
    $14

    Fastest Flights Monday

  • JetSmart
    0h 58m
    0
    7:25 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:23 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $32
  • Sky Airline
    0h 58m
    0
    10:17 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:15 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $33
  • Sky Airline
    0h 58m
    0
    11:32 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:30 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $33
  • LAN Airlines
    0h 58m
    0
    7:11 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:09 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $42
  • LAN Perú
    0h 58m
    0
    6:09 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    7:07 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $48
  • Fastest Buses Monday

  • Cikbus Elité
    5h 55m
    0
    1:35 AM
    La Serena
    Bus Station
    7:30 AM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Economy
    $14
  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $7
  • Condor Bus
    6h 5m
    0
    4:35 PM
    La Serena
    Bus Station
    10:40 PM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Economy
    $12
  • Nueva Andimar Vip
    6h 10m
    0
    9:00 AM
    La Serena
    Bus Station
    3:10 PM
    Santiago, RM
    Sur Bus Station
    0
    Nueva Andimar Vip
    Economy
    $12
  • Buses Romani
    6h 30m
    0
    12:05 AM
    La Serena
    Bus Station
    6:35 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Economy
    $8

    Fastest Flights Tuesday

  • LAN Perú
    0h 56m
    0
    8:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    9:41 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $55
  • LAN Perú
    0h 57m
    0
    9:42 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:39 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $48
  • Sky Airline
    0h 58m
    0
    9:47 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:45 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $44
  • JetSmart
    0h 58m
    0
    10:50 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:48 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $46
  • Fastest Buses Tuesday

  • FlixBus
    6h 5m
    0
    12:05 AM
    La Serena
    Bus Station
    6:10 AM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $7
  • Pullman San Andres
    6h 10m
    0
    12:00 PM
    La Serena
    Bus Station
    6:10 PM
    Santiago, RM
    Terminal San Borja
    0
    Pullman San Andres
    Economy
    $16
  • Buses Romani
    6h 15m
    0
    12:30 AM
    La Serena
    Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    First Class
    $16
  • Buses Paravias
    6h 40m
    0
    11:30 PM
    La Serena
    Bus Stop
    6:10 AM
    Santiago, RM
    Terminal San Borja
    0
    Buses Paravias
    Economy
    $14
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Bus Stop
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $11

    Fastest Flights Wednesday

  • LAN Airlines
    0h 56m
    0
    9:20 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:16 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $54
  • Sky Airline
    0h 58m
    0
    9:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:33 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $33
  • JetSmart
    0h 58m
    0
    9:06 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:04 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $38
  • Air China Cargo
    0h 58m
    0
    9:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:33 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Air China Cargo
    Economy
    from $49
  • LAN Perú
    0h 58m
    0
    3:50 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:48 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $54
  • Fastest Buses Wednesday

  • Cikbus Elité
    6h 0m
    0
    5:00 PM
    La Serena
    Bus Station
    11:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $11
  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $7
  • FlixBus
    6h 5m
    0
    7:00 AM
    La Serena
    Bus Station
    1:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $7
  • Buses Paravias
    6h 40m
    0
    11:30 PM
    La Serena
    Bus Station
    6:10 AM
    Santiago, RM
    Terminal San Borja
    0
    Buses Paravias
    First Class
    $14
  • Cikbus Elité
    7h 15m
    0
    12:35 PM
    La Serena
    Bus Station
    7:50 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $11
Here you will find all operators and timetables for a Bus from La Serena to Santiago, RM

What are the most popular stations in La Serena and Santiago, RM?

In La Serena, you will usually depart from Bus Stop, Corsario or Rotonda, while in Santiago, RM you will be arriving at Terminal San Borja, Los Libertadores Bus Stop or Terminal Pajaritos, but there are many more stops to explore in both locations.

How do I decide? Some tips and tricks from our experience

Are you having trouble deciding on how to get to Santiago, RM from La Serena? With 9 connections between 12 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.

Look for the lowest price

Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between La Serena and Santiago, RM, you can pay as low as $7 with a Bus from FlixBus.

Travel duration

Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LAN Perú: you will get to Santiago, RM in just 0h 56m.

Comfort makes all the difference

You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting La Serena and Santiago, RM are LAN Perú, Sky Airline and FlixBus, but be sure to check what they have to offer!

Save money with deals, and always compare

One last tip? Even if you live in La Serena and Santiago, RM is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from La Florida, La Serena Airport or to Lo Prado, and look at flights from La Florida, La Serena Airport, and landing at Santiago de Chile Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!

Which companies offer a trip from La Serena to Santiago, RM?

The most popular companies between La Serena and Santiago, RM, are LAN Perú, Sky Airline and FlixBus. Be sure to check their seat class offers and the amenities that they provide.

Bus companies: FlixBus, Cikbus Elité, Condor Bus and 6 more.

Airlines: LAN Perú, Sky Airline, LAN Airlines and 2 more.

All you need to know when you travel from La Serena to Santiago, RM

Check all information on comfort and services on all modes of transports from La Serena to Santiago, RM. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.

FAQs about the trip from La Serena to Santiago, RM

How can I reach Santiago, RM from La Serena?

Every day, there are on average 9 connections between Bus and Flight, with which you can get to Santiago, RM from La Serena.

How far is Santiago, RM from La Serena?

The distance between La Serena and Santiago, RM is 247.0 miles.

What is the most ecofriendly mode of transport between La Serena and Santiago, RM?

Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance. On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.

What is the cheapest mode of transport from La Serena to Santiago, RM?

You can get to Santiago, RM with just $7 by taking a Bus from FlixBus.

What is the fastest way to get from La Serena to Santiago, RM?

While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Santiago, RM in just 0h 56m with a Flight from LAN Perú.

More routes to La Serena and to Santiago, RM

Looking for more options? Here you can see the most popular routes to La Serena and to Santiago, RM. Simply click on a connection, and you’ll find all the details about the route!

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