Bus Detroit to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Detroit to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Detroit to Greenville, SC from various bus operators like Greyhound US for the next days.

today

from $93

tomorrow

Thursday

from $114

Friday

from $83

Saturday

from $78

Sunday

Monday

Cheapest bus trips today

Prices are for one way and one person
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	18h 20m	8:15 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd		Economy	$93	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 7/29/2025 8:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2025 2:35:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 18h 20m
	Greyhound US	24h 50m	6:40 AM	Detroit	Central Bus Station	7:30 AM	Greenville, SC	Woodruff Rd		Economy	$94	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 7/29/2025 6:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2025 7:30:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 24h 50m

Cheapest bus trips Thursday

Prices are for one way and one person
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	24h 50m	6:40 AM	Detroit	Central Bus Station	7:30 AM	Greenville, SC	Woodruff Rd		Economy	$114	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 7/31/2025 6:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/1/2025 7:30:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 24h 50m
	Greyhound US	18h 20m	8:15 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd		Economy	$114	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 7/31/2025 8:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/1/2025 2:35:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 18h 20m

Did you know that if you travel from Detroit to Greenville, SC via Charlotte, you can save more than $12? You can find the corresponding connections below.
- FlixBus
  
  23h 25m
  
  0
  
  8:15 PM
  
  Detroit
  Central Bus Station
  
  11:50 AM
  
  Charlotte
  W Trade St
  
  0
  
  Economy
  
  $82
  
  A Bus from FlixBus goes from Central Bus Station, Detroit (USA) at 8/1/2025 8:15:00 PM to W Trade St, Charlotte (USA) arriving at 8/2/2025 11:50:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 15h 35m
- Busbud
  
  2h 0m
  
  0
  
  5:40 PM
  
  Charlotte
  W Trade St
  
  7:40 PM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $20
  
  A Bus from Busbud goes from W Trade St, Charlotte (USA) at 8/2/2025 5:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/2/2025 7:40:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 2h 0m
Travel time is 5h 5m longer, but you will save $12

Cheapest bus trips Friday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	24h 50m	6:40 AM	Detroit	Central Bus Station	7:30 AM	Greenville, SC	Woodruff Rd	Economy	$83	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/1/2025 6:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/2/2025 7:30:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 24h 50m
Greyhound US	18h 20m	8:15 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$85	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/1/2025 8:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/2/2025 2:35:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 18h 20m
Greyhound US	24h 50m	6:40 AM	Detroit	Central Bus Station	7:30 AM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/1/2025 6:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/2/2025 7:30:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 24h 50m
Greyhound US	18h 20m	8:15 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$88	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/1/2025 8:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/2/2025 2:35:00 PM. 50 Economy ticket for $88 per person are available. Travel duration is 18h 20m

Cheapest bus trips Saturday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	24h 50m	6:40 AM	Detroit	Central Bus Station	7:30 AM	Greenville, SC	Woodruff Rd	Economy	$78	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/2/2025 6:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/3/2025 7:30:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 24h 50m
Greyhound US	18h 20m	8:15 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$80	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/2/2025 8:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/3/2025 2:35:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 18h 20m
Greyhound US	24h 50m	6:40 AM	Detroit	Central Bus Station	7:30 AM	Greenville, SC	Woodruff Rd	Economy	$114	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/2/2025 6:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/3/2025 7:30:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 24h 50m
Greyhound US	18h 20m	8:15 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$114	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/2/2025 8:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/3/2025 2:35:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 18h 20m

Frequency of bus connections between Detroit and Greenville, SC

See here how frequent the connections between Detroit and Greenville, SC are, during different times and days of the week.

Friday is the busiest day, with more than 4 daily buses from Detroit to Greenville, SC. Tuesday has instead the fewest connections, with only 2 daily coaches between Detroit and Greenville, SC.

The busiest time of the day is the Morning, with 6 buses from Detroit to Greenville, SC, while Morning sees the fewest connections between Detroit and Greenville, SC, with 6 offers.

Facts about the bus from Detroit to Greenville, SC

Compare all providers like Greyhound US that travel 3 times every day by bus from Detroit to Greenville, SC in one click! Book your bus ticket from Detroit to Greenville, SC starting from $78!

Cheapest Bus	$78
Fastest Bus	18h 20m
Earliest Bus	6:40 AM
Latest Bus	8:15 PM
Daily Bus Routes	3 Ø
Distance	518.2 miles
Bus Companies	Greyhound US

Cheapest bus connections from Detroit to Greenville, SC

Every day, 3 buses from 1 bus companies leave Detroit for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/29/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/27

Monday 07/28

Tuesday 07/29

$93

Wednesday 07/30

Thursday 07/31

$114

Friday 08/01

$83

Saturday 08/02

$114

Sunday 08/03

Monday 08/04

Tuesday 08/05

$110

Wednesday 08/06

Thursday 08/07

$87

Friday 08/08

Saturday 08/09

Sunday 08/10

$86

Monday 08/11

Tuesday 08/12

Wednesday 08/13

$81

Thursday 08/14

Friday 08/15

Saturday 08/16

Sunday 08/17

$78

Monday 08/18

Tuesday 08/19

Wednesday 08/20

Thursday 08/21

$90

Friday 08/22

$85

Saturday 08/23

The cheapest time to travel from Detroit to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Detroit to Greenville, SC, for the next 30 days.

With a price starting from $78, Saturday is the cheapest day for a bus from Detroit to Greenville, SC. Thursday instead is the most expensive day with prices starting from $113.

Morning is the cheapest day time for bus tickets from Detroit to Greenville, SC, with $78. Evening is the most expensive time of the day with prices starting from $80.

How to save money travelling from Detroit to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Detroit to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Detroit to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Detroit to Greenville, SC are also emptier.

All bus stations and stops in Detroit and Greenville, SC

In the map below, you can see where to find all bus stations in Detroit and Greenville, SC.

Central Bus Station

Howard St 1001

Amtrak

W Baltimore Ave 78

VA Medical Center Blue Deck

East Canfield Street (between John R. and Brush St.) 225

Park Avenue

Rosa Parks TC

Cass Ave 1310

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

N Church St

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Service and Comfort on the bus from Detroit to Greenville, SC

Want to know which seat classes are available on the buses from Detroit to Greenville, SC? Or which bus companies serve the route Detroit to Greenville, SC? Below you will find answers to your questions.

FAQs about the Detroit to Greenville, SC bus

How much does a Detroit Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $78 and takes 24h 50m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Detroit to Greenville, SC?

This route is offered by 1 companies with a range of ticket prices between $78 and $114. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Detroit to Greenville, SC each day?

Every day, the Detroit to Greenville, SC bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Detroit to Greenville, SC take?

The fastest bus from Detroit to Greenville, SC is offered by Greyhound US and takes 18h 20m. Bus tickets for this connection cost $93. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Detroit to Greenville, SC?

The earliest bus arriving in Greenville, SC from Detroit starts at 6:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Detroit to Greenville, SC?

The latest bus trip departing from Detroit for Greenville, SC starts at 8:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Detroit Greenville, SC route?

When traveling by bus from Detroit to Greenville, SC, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Detroit and Greenville, SC?

You can check all the direct connections between Detroit and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Detroit to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Detroit Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Detroit Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Detroit to Greenville, SC on your planned travel date.

Available seat classes which are offered on the bus route Detroit to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Detroit and to Greenville, SC

Here’s an overview of the most popular bus routes to Detroit and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!