Bus Chicago to Greenville, SC - Compare all Companies

Compare all timetables for the bus from Chicago to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Chicago to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

Monday

$133

Tuesday

$149

Wednesday

$148

Thursday

$121

Friday

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	20h 10m	1:30 PM	Chicago	95th Red Line Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$133	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/22/2025 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 10:40:00 AM. 50 Economy ticket for $133 per person are available. Travel duration is 20h 10m
Greyhound US	20h 50m	2:10 PM	Chicago	95th Red Line Station	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$134	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/22/2025 2:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 12:00:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 20h 50m
FlixBus	20h 30m	6:40 PM	Chicago	95th Red Line Station	4:10 PM	Greenville, SC	Woodruff Rd	Economy	$135	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/22/2025 6:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 4:10:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 20h 30m
FlixBus	30h 15m	11:50 PM	Chicago	95th Red Line Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$135	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/22/2025 11:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 7:05:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 30h 15m
Greyhound US	20h 15m	2:45 PM	Chicago	Downtown Bus Station	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$145	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/22/2025 2:45:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 12:00:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 20h 15m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 15m	2:45 PM	Chicago	Downtown Bus Station	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$149	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/23/2025 2:45:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 12:00:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 20h 15m
Greyhound US	22h 5m	10:50 PM	Chicago	Downtown Bus Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$161	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/23/2025 10:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 9:55:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 22h 5m
Greyhound US	21h 45m	11:10 PM	Chicago	Union Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$161	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/23/2025 11:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 9:55:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 21h 45m
FlixBus	21h 10m	6:00 PM	Chicago	Downtown Bus Station	4:10 PM	Greenville, SC	Woodruff Rd	Economy	$165	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/23/2025 6:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 4:10:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 21h 10m
FlixBus	20h 40m	1:00 PM	Chicago	Downtown Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$181	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/23/2025 1:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 10:40:00 AM. 50 Economy ticket for $181 per person are available. Travel duration is 20h 40m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	20h 40m	1:00 PM	Chicago	Downtown Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$148	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/24/2025 1:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 10:40:00 AM. 50 Economy ticket for $148 per person are available. Travel duration is 20h 40m
Greyhound US	20h 15m	2:45 PM	Chicago	Downtown Bus Station	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$149	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/24/2025 2:45:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 12:00:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 20h 15m
Greyhound US	22h 5m	10:50 PM	Chicago	Downtown Bus Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$149	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/24/2025 10:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 9:55:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 22h 5m
Greyhound US	21h 45m	11:10 PM	Chicago	Union Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$149	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/24/2025 11:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 9:55:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 21h 45m
FlixBus	21h 10m	6:00 PM	Chicago	Downtown Bus Station	4:10 PM	Greenville, SC	Woodruff Rd	Economy	$149	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/24/2025 6:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 4:10:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 21h 10m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 50m	2:10 PM	Chicago	95th Red Line Station	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$121	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/25/2025 2:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/26/2025 12:00:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 20h 50m
FlixBus	20h 10m	1:30 PM	Chicago	95th Red Line Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$122	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/25/2025 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/26/2025 10:40:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 20h 10m
FlixBus	24h 20m	5:45 AM	Chicago	95th Red Line Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$123	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/25/2025 5:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/26/2025 7:05:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 24h 20m
FlixBus	20h 30m	6:40 PM	Chicago	95th Red Line Station	4:10 PM	Greenville, SC	Woodruff Rd	Economy	$123	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/25/2025 6:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/26/2025 4:10:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 20h 30m
Greyhound US	20h 25m	9:40 AM	Chicago	Downtown Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$124	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/25/2025 9:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/26/2025 7:05:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 20h 25m

Best Price Offer: The price for the cheapest bus from Chicago to Greenville, SC is $99 on 1/8/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and Greenville, SC

See here how frequent the connections between Chicago and Greenville, SC are, during different times and days of the week.

Monday is the busiest day, with more than 26 daily buses from Chicago to Greenville, SC. Tuesday has instead the fewest connections, with only 7 daily coaches between Chicago and Greenville, SC.

The busiest time of the day is the Evening, with 30 buses from Chicago to Greenville, SC, while Night sees the fewest connections between Chicago and Greenville, SC, with 4 offers.

Facts about the bus from Chicago to Greenville, SC

Compare all providers like Greyhound US and FlixBus that travel 16 times every day by bus from Chicago to Greenville, SC in one click! Book your bus ticket from Chicago to Greenville, SC starting from $99!

Cheapest Bus	$99
Fastest Bus	21h 5m
Earliest Bus	5:45 AM
Latest Bus	11:59 PM
Daily Bus Routes	16 Ø
Distance	562.3 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Chicago to Greenville, SC

Every day, 16 buses from 2 bus companies leave Chicago for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/20/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

$134

Tuesday 12/23

$149

Wednesday 12/24

$148

Thursday 12/25

$121

Friday 12/26

Saturday 12/27

Sunday 12/28

$146

Monday 12/29

Tuesday 12/30

$129

Wednesday 12/31

Thursday 01/01

$116

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

$99

Friday 01/09

Saturday 01/10

The cheapest time to travel from Chicago to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Greenville, SC, for the next 30 days.

With a price starting from $99, Thursday is the cheapest day for a bus from Chicago to Greenville, SC. Wednesday instead is the most expensive day with prices starting from $148.

Night is the cheapest day time for bus tickets from Chicago to Greenville, SC, with $99. Morning is the most expensive time of the day with prices starting from $124.

How to save money travelling from Chicago to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Greenville, SC are also emptier.

All bus stations and stops in Chicago and Greenville, SC

In the map below, you can see where to find all bus stations in Chicago and Greenville, SC.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Service and Comfort on the bus from Chicago to Greenville, SC

Want to know which seat classes are available on the buses from Chicago to Greenville, SC? Or which bus companies serve the route Chicago to Greenville, SC? Below you will find answers to your questions.

FAQs about the Chicago to Greenville, SC bus

How much does a Chicago Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $99 and takes 21h 50m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Chicago to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $99 and $181. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Chicago to Greenville, SC each day?

Every day, the Chicago to Greenville, SC bus route is served by approximately 16 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Greenville, SC take?

The fastest bus from Chicago to Greenville, SC is offered by Greyhound US and takes 21h 5m. Bus tickets for this connection cost $157. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Greenville, SC?

The earliest bus arriving in Greenville, SC from Chicago starts at 5:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Greenville, SC?

The latest bus trip departing from Chicago for Greenville, SC starts at 11:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Greenville, SC route?

When traveling by bus from Chicago to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Greenville, SC?

You can check all the direct connections between Chicago and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 16 daily trips between Chicago and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to Greenville, SC?

Prices and availability for 16 trips between Chicago and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Greenville, SC

Here’s an overview of the most popular bus routes to Chicago and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!