Bus from Knoxville, TN to Chicago from $96

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Compare all timetables for the bus from Knoxville, TN to Chicago

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to Chicago from various bus operators like Greyhound US for the next days.

today
from $128
tomorrow
from $96
Tuesday
from $117
Wednesday
Thursday
from $112
Friday
from $110
Saturday
from $108

Cheapest bus trips today

Prices are for one way and one person
Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 16h 0m 10:00 PM Knoxville, TN Greyhound Bus Station 2:00 PM Chicago 95th Red Line Station  Economy $128
Greyhound US 16h 30m 10:00 PM Knoxville, TN Greyhound Bus Station 2:30 PM Chicago Downtown Bus Station  Economy $151
Greyhound US 15h 35m 6:15 PM Knoxville, TN Greyhound Bus Station 9:50 AM Chicago 95th Red Line Station  Economy $153
Greyhound US 13h 40m 6:15 PM Knoxville, TN Greyhound Bus Station 7:55 AM Chicago Union Station  Economy $177
Greyhound US 14h 0m 6:15 PM Knoxville, TN Greyhound Bus Station 8:15 AM Chicago Downtown Bus Station  Economy $177
  • Did you know that if you travel from Knoxville, TN to Chicago via Louisville, KY, you can save more than $24? You can find the corresponding connections below.
    • FlixBus
      13h 40m
      0
      6:15 PM
      Knoxville, TN
      Greyhound Bus Station
      1:30 AM
      Louisville, KY
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $52
    • Waiting Time 1h 25m
    • Busbud
      5h 0m
      0
      2:55 AM
      Louisville, KY
      Greyhound Bus Station
      7:55 AM
      Chicago
      Canal & Van Buren
      0
      Busbud
      Economy
      $52
    Travel time is the same as the direct connection, but you will save $24

Cheapest bus trips tomorrow

Prices are for one way and one person
Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 16h 0m 10:00 PM Knoxville, TN Greyhound Bus Station 2:00 PM Chicago 95th Red Line Station  Economy $96
Greyhound US 16h 30m 10:00 PM Knoxville, TN Greyhound Bus Station 2:30 PM Chicago Downtown Bus Station  Economy $119
Greyhound US 15h 35m 6:15 PM Knoxville, TN Greyhound Bus Station 9:50 AM Chicago 95th Red Line Station  Economy $120
Greyhound US 13h 40m 6:15 PM Knoxville, TN Greyhound Bus Station 7:55 AM Chicago Union Station  Economy $139
Greyhound US 14h 0m 6:15 PM Knoxville, TN Greyhound Bus Station 8:15 AM Chicago Downtown Bus Station  Economy $139

Cheapest bus trips Tuesday

Prices are for one way and one person
Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 16h 0m 10:00 PM Knoxville, TN Greyhound Bus Station 2:00 PM Chicago 95th Red Line Station  Economy $117
Greyhound US 16h 30m 10:00 PM Knoxville, TN Greyhound Bus Station 2:30 PM Chicago Downtown Bus Station  Economy $134
Greyhound US 15h 35m 6:15 PM Knoxville, TN Greyhound Bus Station 9:50 AM Chicago 95th Red Line Station  Economy $135
Greyhound US 13h 40m 6:15 PM Knoxville, TN Greyhound Bus Station 7:55 AM Chicago Union Station  Economy $151
Greyhound US 14h 0m 6:15 PM Knoxville, TN Greyhound Bus Station 8:15 AM Chicago Downtown Bus Station  Economy $151
  • Did you know that if you travel from Knoxville, TN to Chicago via Louisville, KY, you can save more than $22? You can find the corresponding connections below.
    • FlixBus
      16h 50m
      0
      6:15 PM
      Knoxville, TN
      Greyhound Bus Station
      1:30 AM
      Louisville, KY
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $52
    • Waiting Time 3h 20m
    • Busbud
      6h 15m
      0
      4:50 AM
      Louisville, KY
      Greyhound Bus Station
      11:05 AM
      Chicago
      95th Red Line Station
      0
      Busbud
      Economy
      $43
    Travel time is 3h 10m longer, but you will save $22

Cheapest bus trips Thursday

Prices are for one way and one person
Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 16h 0m 10:00 PM Knoxville, TN Greyhound Bus Station 2:00 PM Chicago 95th Red Line Station  Economy $112
Greyhound US 16h 30m 10:00 PM Knoxville, TN Greyhound Bus Station 2:30 PM Chicago Downtown Bus Station  Economy $127
Greyhound US 15h 35m 6:15 PM Knoxville, TN Greyhound Bus Station 9:50 AM Chicago 95th Red Line Station  Economy $134
Greyhound US 13h 40m 6:15 PM Knoxville, TN Greyhound Bus Station 7:55 AM Chicago Union Station  Economy $146
Greyhound US 14h 0m 6:15 PM Knoxville, TN Greyhound Bus Station 8:15 AM Chicago Downtown Bus Station  Economy $146
  • Did you know that if you travel from Knoxville, TN to Chicago via Louisville, KY, you can save more than $17? You can find the corresponding connections below.
    • FlixBus
      16h 50m
      0
      6:15 PM
      Knoxville, TN
      Greyhound Bus Station
      1:30 AM
      Louisville, KY
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $52
    • Waiting Time 3h 20m
    • Busbud
      6h 15m
      0
      4:50 AM
      Louisville, KY
      Greyhound Bus Station
      11:05 AM
      Chicago
      95th Red Line Station
      0
      Busbud
      Economy
      $43
    Travel time is 3h 10m longer, but you will save $17

Cheapest bus trips Friday

Prices are for one way and one person
Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 16h 0m 10:00 PM Knoxville, TN Greyhound Bus Station 2:00 PM Chicago 95th Red Line Station  Economy $110
Greyhound US 16h 30m 10:00 PM Knoxville, TN Greyhound Bus Station 2:30 PM Chicago Downtown Bus Station  Economy $126
Greyhound US 15h 35m 6:15 PM Knoxville, TN Greyhound Bus Station 9:50 AM Chicago 95th Red Line Station  Economy $133
Greyhound US 13h 40m 6:15 PM Knoxville, TN Greyhound Bus Station 7:55 AM Chicago Union Station  Economy $150
Greyhound US 14h 0m 6:15 PM Knoxville, TN Greyhound Bus Station 8:15 AM Chicago Downtown Bus Station  Economy $150
  • Did you know that if you travel from Knoxville, TN to Chicago via Louisville, KY, you can save more than $15? You can find the corresponding connections below.
    • FlixBus
      16h 50m
      0
      6:15 PM
      Knoxville, TN
      Greyhound Bus Station
      1:30 AM
      Louisville, KY
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $52
    • Waiting Time 3h 20m
    • Busbud
      6h 15m
      0
      4:50 AM
      Louisville, KY
      Greyhound Bus Station
      11:05 AM
      Chicago
      95th Red Line Station
      0
      Busbud
      Economy
      $43
    Travel time is 3h 10m longer, but you will save $15

Cheapest bus trips Saturday

Prices are for one way and one person
Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 16h 0m 10:00 PM Knoxville, TN Greyhound Bus Station 2:00 PM Chicago 95th Red Line Station  Economy $108
Greyhound US 16h 30m 10:00 PM Knoxville, TN Greyhound Bus Station 2:30 PM Chicago Downtown Bus Station  Economy $122
Greyhound US 15h 35m 6:15 PM Knoxville, TN Greyhound Bus Station 9:50 AM Chicago 95th Red Line Station  Economy $147
Greyhound US 14h 0m 6:15 PM Knoxville, TN Greyhound Bus Station 8:15 AM Chicago Downtown Bus Station  Economy $160
Greyhound US 13h 40m 6:15 PM Knoxville, TN Greyhound Bus Station 7:55 AM Chicago Union Station  Economy $160
  • Did you know that if you travel from Knoxville, TN to Chicago via Louisville, KY, you can save more than $13? You can find the corresponding connections below.
    • FlixBus
      16h 50m
      0
      6:15 PM
      Knoxville, TN
      Greyhound Bus Station
      1:30 AM
      Louisville, KY
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $52
    • Waiting Time 3h 20m
    • Busbud
      6h 15m
      0
      4:50 AM
      Louisville, KY
      Greyhound Bus Station
      11:05 AM
      Chicago
      95th Red Line Station
      0
      Busbud
      Economy
      $43
    Travel time is 3h 10m longer, but you will save $13

Facts about the bus from Knoxville, TN to Chicago

Compare all providers like Greyhound US that travel 5 times every day by bus from Knoxville, TN to Chicago in one click! Book your bus ticket from Knoxville, TN to Chicago starting from $96!

Cheapest Bus $96
Fastest Bus 13h 40m
Earliest Bus 6:15 PM
Latest Bus 10:00 PM
Daily Bus Routes 5 Ø
Distance 455.0 miles
Bus Companies Greyhound US

Cheapest bus connections from Knoxville, TN to Chicago

Every day, 5 buses from 1 bus companies leave Knoxville, TN for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/27/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 07/27
$119
Monday 07/28
$81
Tuesday 07/29
$116
Wednesday 07/30
Thursday 07/31
$111
Friday 08/01
$110
Saturday 08/02
$122
Sunday 08/03
Monday 08/04
$126
Tuesday 08/05
Wednesday 08/06
Thursday 08/07
Friday 08/08
$89
Saturday 08/09
Sunday 08/10
Monday 08/11
Tuesday 08/12
Wednesday 08/13
Thursday 08/14
Friday 08/15
$91
Saturday 08/16
Sunday 08/17
Monday 08/18
$85
Tuesday 08/19
Wednesday 08/20
Thursday 08/21
Friday 08/22
$72
Saturday 08/23

How to save money travelling from Knoxville, TN to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to Chicago are also emptier.

All bus stations and stops in Knoxville, TN and Chicago

In the map below, you can see where to find all bus stations in Knoxville, TN and Chicago.

Service and Comfort on the bus from Knoxville, TN to Chicago

Want to know which seat classes are available on the buses from Knoxville, TN to Chicago? Or which bus companies serve the route Knoxville, TN to Chicago? Below you will find answers to your questions.

FAQs about the Knoxville, TN to Chicago bus

How much does a Knoxville, TN Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $96 and takes 16h 0m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to Chicago?

This route is offered by 1 companies with a range of ticket prices between $96 and $177. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Knoxville, TN to Chicago each day?

Every day, the Knoxville, TN to Chicago bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to Chicago take?

The fastest bus from Knoxville, TN to Chicago is offered by Greyhound US and takes 13h 40m. Bus tickets for this connection cost $177. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to Chicago?

The earliest bus arriving in Chicago from Knoxville, TN starts at 6:15 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to Chicago?

The latest bus trip departing from Knoxville, TN for Chicago starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN Chicago route?

When traveling by bus from Knoxville, TN to Chicago, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and Chicago?

You can check all the direct connections between Knoxville, TN and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to Chicago on your planned travel date.

Available seat classes which are offered on the bus route Knoxville, TN to Chicago

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to Chicago

Here’s an overview of the most popular bus routes to Knoxville, TN and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!

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