Compare all timetables for the bus from Knoxville, TN to Chicago
Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
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Greyhound US | 16h 0m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:00 PM | Chicago | 95th Red Line Station | Economy | $128 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/27/2025 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/28/2025 2:00:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 16h 0m
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Greyhound US | 16h 30m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:30 PM | Chicago | Downtown Bus Station | Economy | $151 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/27/2025 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/28/2025 2:30:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 16h 30m
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Greyhound US | 15h 35m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 9:50 AM | Chicago | 95th Red Line Station | Economy | $153 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/27/2025 6:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/28/2025 9:50:00 AM. 50 Economy ticket for $153 per person are available. Travel duration is 15h 35m
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Greyhound US | 13h 40m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 7:55 AM | Chicago | Union Station | Economy | $177 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/27/2025 6:15:00 PM to Union Station, Chicago (USA) arriving at 7/28/2025 7:55:00 AM. 50 Economy ticket for $177 per person are available. Travel duration is 13h 40m
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Greyhound US | 14h 0m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 8:15 AM | Chicago | Downtown Bus Station | Economy | $177 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/27/2025 6:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/28/2025 8:15:00 AM. 50 Economy ticket for $177 per person are available. Travel duration is 14h 0m
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FlixBus13h 40m06:15 PMKnoxville, TNGreyhound Bus Station1:30 AMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/29/2025 6:15:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 7/30/2025 1:30:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 7h 15m
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Busbud5h 0m02:55 AMLouisville, KYGreyhound Bus Station7:55 AMChicagoCanal & Van Buren0EconomyA Bus from Busbud goes from Greyhound Bus Station, Louisville, KY (USA) at 7/30/2025 2:55:00 AM to Canal & Van Buren, Chicago (USA) arriving at 7/30/2025 7:55:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 5h 0m
Waiting Time 1h 25m -
Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
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Greyhound US | 16h 0m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:00 PM | Chicago | 95th Red Line Station | Economy | $96 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/28/2025 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/29/2025 2:00:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 16h 0m
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Greyhound US | 16h 30m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:30 PM | Chicago | Downtown Bus Station | Economy | $119 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/28/2025 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/29/2025 2:30:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 16h 30m
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Greyhound US | 15h 35m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 9:50 AM | Chicago | 95th Red Line Station | Economy | $120 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/28/2025 6:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/29/2025 9:50:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 15h 35m
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Greyhound US | 13h 40m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 7:55 AM | Chicago | Union Station | Economy | $139 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/28/2025 6:15:00 PM to Union Station, Chicago (USA) arriving at 7/29/2025 7:55:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 13h 40m
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Greyhound US | 14h 0m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 8:15 AM | Chicago | Downtown Bus Station | Economy | $139 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/28/2025 6:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/29/2025 8:15:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 14h 0m
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Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
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Greyhound US | 16h 0m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:00 PM | Chicago | 95th Red Line Station | Economy | $117 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/29/2025 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2025 2:00:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 16h 0m
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Greyhound US | 16h 30m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:30 PM | Chicago | Downtown Bus Station | Economy | $134 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/29/2025 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/30/2025 2:30:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 16h 30m
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Greyhound US | 15h 35m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 9:50 AM | Chicago | 95th Red Line Station | Economy | $135 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/29/2025 6:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2025 9:50:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 15h 35m
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Greyhound US | 13h 40m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 7:55 AM | Chicago | Union Station | Economy | $151 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/29/2025 6:15:00 PM to Union Station, Chicago (USA) arriving at 7/30/2025 7:55:00 AM. 50 Economy ticket for $151 per person are available. Travel duration is 13h 40m
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Greyhound US | 14h 0m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 8:15 AM | Chicago | Downtown Bus Station | Economy | $151 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/29/2025 6:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/30/2025 8:15:00 AM. 50 Economy ticket for $151 per person are available. Travel duration is 14h 0m
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FlixBus16h 50m06:15 PMKnoxville, TNGreyhound Bus Station1:30 AMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/29/2025 6:15:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 7/30/2025 1:30:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 7h 15m
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Busbud6h 15m04:50 AMLouisville, KYGreyhound Bus Station11:05 AMChicago95th Red Line Station0EconomyA Bus from Busbud goes from Greyhound Bus Station, Louisville, KY (USA) at 7/30/2025 4:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2025 11:05:00 AM. 50 Economy ticket for $43 per person are available. Travel duration is 6h 15m
Waiting Time 3h 20m -
Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
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Greyhound US | 16h 0m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:00 PM | Chicago | 95th Red Line Station | Economy | $112 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/31/2025 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 8/1/2025 2:00:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 16h 0m
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Greyhound US | 16h 30m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:30 PM | Chicago | Downtown Bus Station | Economy | $127 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/31/2025 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 8/1/2025 2:30:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 16h 30m
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Greyhound US | 15h 35m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 9:50 AM | Chicago | 95th Red Line Station | Economy | $134 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/31/2025 6:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 8/1/2025 9:50:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 15h 35m
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Greyhound US | 13h 40m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 7:55 AM | Chicago | Union Station | Economy | $146 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/31/2025 6:15:00 PM to Union Station, Chicago (USA) arriving at 8/1/2025 7:55:00 AM. 50 Economy ticket for $146 per person are available. Travel duration is 13h 40m
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Greyhound US | 14h 0m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 8:15 AM | Chicago | Downtown Bus Station | Economy | $146 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/31/2025 6:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 8/1/2025 8:15:00 AM. 50 Economy ticket for $146 per person are available. Travel duration is 14h 0m
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FlixBus16h 50m06:15 PMKnoxville, TNGreyhound Bus Station1:30 AMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/29/2025 6:15:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 7/30/2025 1:30:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 7h 15m
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Busbud6h 15m04:50 AMLouisville, KYGreyhound Bus Station11:05 AMChicago95th Red Line Station0EconomyA Bus from Busbud goes from Greyhound Bus Station, Louisville, KY (USA) at 7/30/2025 4:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2025 11:05:00 AM. 50 Economy ticket for $43 per person are available. Travel duration is 6h 15m
Waiting Time 3h 20m -
Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
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Greyhound US | 16h 0m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:00 PM | Chicago | 95th Red Line Station | Economy | $110 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/1/2025 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 8/2/2025 2:00:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 16h 0m
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Greyhound US | 16h 30m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:30 PM | Chicago | Downtown Bus Station | Economy | $126 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/1/2025 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 8/2/2025 2:30:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 16h 30m
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Greyhound US | 15h 35m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 9:50 AM | Chicago | 95th Red Line Station | Economy | $133 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/1/2025 6:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 8/2/2025 9:50:00 AM. 50 Economy ticket for $133 per person are available. Travel duration is 15h 35m
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Greyhound US | 13h 40m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 7:55 AM | Chicago | Union Station | Economy | $150 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/1/2025 6:15:00 PM to Union Station, Chicago (USA) arriving at 8/2/2025 7:55:00 AM. 50 Economy ticket for $150 per person are available. Travel duration is 13h 40m
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Greyhound US | 14h 0m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 8:15 AM | Chicago | Downtown Bus Station | Economy | $150 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/1/2025 6:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 8/2/2025 8:15:00 AM. 50 Economy ticket for $150 per person are available. Travel duration is 14h 0m
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FlixBus16h 50m06:15 PMKnoxville, TNGreyhound Bus Station1:30 AMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/29/2025 6:15:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 7/30/2025 1:30:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 7h 15m
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Busbud6h 15m04:50 AMLouisville, KYGreyhound Bus Station11:05 AMChicago95th Red Line Station0EconomyA Bus from Busbud goes from Greyhound Bus Station, Louisville, KY (USA) at 7/30/2025 4:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2025 11:05:00 AM. 50 Economy ticket for $43 per person are available. Travel duration is 6h 15m
Waiting Time 3h 20m -
Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
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Greyhound US | 16h 0m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:00 PM | Chicago | 95th Red Line Station | Economy | $108 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/2/2025 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 8/3/2025 2:00:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 16h 0m
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Greyhound US | 16h 30m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 2:30 PM | Chicago | Downtown Bus Station | Economy | $122 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/2/2025 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 8/3/2025 2:30:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 16h 30m
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Greyhound US | 15h 35m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 9:50 AM | Chicago | 95th Red Line Station | Economy | $147 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/2/2025 6:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 8/3/2025 9:50:00 AM. 50 Economy ticket for $147 per person are available. Travel duration is 15h 35m
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Greyhound US | 14h 0m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 8:15 AM | Chicago | Downtown Bus Station | Economy | $160 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/2/2025 6:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 8/3/2025 8:15:00 AM. 50 Economy ticket for $160 per person are available. Travel duration is 14h 0m
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Greyhound US | 13h 40m | 6:15 PM | Knoxville, TN | Greyhound Bus Station | 7:55 AM | Chicago | Union Station | Economy | $160 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/2/2025 6:15:00 PM to Union Station, Chicago (USA) arriving at 8/3/2025 7:55:00 AM. 50 Economy ticket for $160 per person are available. Travel duration is 13h 40m
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FlixBus16h 50m06:15 PMKnoxville, TNGreyhound Bus Station1:30 AMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/29/2025 6:15:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 7/30/2025 1:30:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 7h 15m
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Busbud6h 15m04:50 AMLouisville, KYGreyhound Bus Station11:05 AMChicago95th Red Line Station0EconomyA Bus from Busbud goes from Greyhound Bus Station, Louisville, KY (USA) at 7/30/2025 4:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2025 11:05:00 AM. 50 Economy ticket for $43 per person are available. Travel duration is 6h 15m
Waiting Time 3h 20m -
Facts about the bus from Knoxville, TN to Chicago
Compare all providers like Greyhound US that travel 5 times every day by bus from Knoxville, TN to Chicago in one click! Book your bus ticket from Knoxville, TN to Chicago starting from $96!
Cheapest Bus | $96 |
Fastest Bus | 13h 40m |
Earliest Bus | 6:15 PM |
Latest Bus | 10:00 PM |
Daily Bus Routes | 5 Ø |
Distance | 455.0 miles |
Bus Companies | Greyhound US |
Cheapest bus connections from Knoxville, TN to Chicago
Every day, 5 buses from 1 bus companies leave Knoxville, TN for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/27/2025 and for the following days.
How to save money travelling from Knoxville, TN to Chicago
Book the ticket from Knoxville, TN to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to Chicago, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to Chicago are also emptier.All bus stations and stops in Knoxville, TN and Chicago
In the map below, you can see where to find all bus stations in Knoxville, TN and Chicago.
Service and Comfort on the bus from Knoxville, TN to Chicago
FAQs about the Knoxville, TN to Chicago bus
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Available seat classes which are offered on the bus route Knoxville, TN to Chicago
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
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